Postoperative nausea and vomiting,Postoperative pain
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 75 years (2) American Society of Anesthesiologists (ASA) physical status I-III (3) Body mass index (BMI) 18.5-28 kg/m² (4) Operation duration 1 to 3 hours (5) Patients undergoing elective radical thyroidectomy or partial thyroidectomy (6) Understand the purpose of the study, agree to the protocol, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with pre-existing chronic pain in the observation area. (2) Regular use of drugs with known antiemetic properties. (3) Local infection or trauma at acupuncture points. (4) Trigeminal neuralgia and hemifacial spasm. (5) History of facial cosmetic surgery. (6) Coagulation disorders. (7) Long-term use of anticoagulants. (8) Severe diabetes mellitus, hypertension, coronary artery disease, severe hepatic or renal insufficiency. (9) Previous cerebrovascular events, mental disorders, or inability to communicate. (10) Postoperative admission to the intensive care unit (ICU). (11) Hypersensitivity to any drug used in the trial. (12) History of sedative, antidepressant, or anxiolytic use; history of drug or alcohol dependence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of nausea and vomiting within 48 hours after the operation;VAS scores of pain at different time points after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative dosage of propofol;Intraoperative dosage of remifentanil;Medication name, dosage and frequency of postoperative supplementary analgesics and antiemetics.;QoR-15 score at 48 h after surgery.; Postoperative sedation score.;PSQI on postoperative day 1 and 2;incidence of POSD at 48 h after surgery.; | — |
Countries
The People's Republic of China
Contacts
Dalian Medical University Affiliated Second Hospital