Bipolar disorder
Conditions
Interventions
Health Group:None
Depressive State True Ear Acupoint Electroacupuncture Group:Auricular Acupoint Electrical Stimulation Therapy
Depression item fake ear acupoint electroacupuncture group:Electroacupuncture Therapy at Pseudo-Auricular Points
Sponsors
Yunnan University of Traditional Chinese Medicine Second Affiliated Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 25 Years
Inclusion criteria
Inclusion criteria: 1) Meets the diagnostic criteria for bipolar disorder according to DSM-5, aged 12–25 years, gender; 2) For depressive-phase patients, the score on the 24-item Hamilton Depression Rating Scale (HAMD-24) must be =17, and the YMRS score must be =5; 3) Right-handed; 4) No prior systematic standardized treatment; 5) Able to understand and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Age greater than 25 years or less than 12 years; 2) Received modified electroconvulsive therapy or transcranial magnetic direct current stimulation treatment in the past month; 3) History of schizophrenia or schizoaffective disorder; 4) Severe somatic diseases or organic brain diseases; 5) Severe impulsivity and suicidal tendencies, with a suicide score of =3 points on the Hamilton Depression Rating Scale; 6) Contraindications for MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting-state brain function magnetic resonance;Clinical Overall Efficacy Assessment;Transition to Agitation Rate;Proteome Sequencing;Transcriptome sequencing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Rating Scale;24-item Hamilton Depression Rating Scale score;32-item hypomania symptom checklist;Traditional Chinese Medicine Syndrome Scoring Scale Assessment;Pittsburgh Sleep Quality Index Score;Childhood Trauma Questionnaire;Adverse Reaction Scale (TESS) Scoring; | — |
Countries
China
Contacts
Public ContactLiu Haijing
Yunnan University of Traditional Chinese Medicine Second Affiliated Hospital
Outcome results
None listed