isolated premature thelarche
Conditions
Interventions
Control Group:Basic interventions: 1) Control diet
2) Maintain regular sleep schedule
3) Emotional regulation
Trial Group A:Basic intervention + Zhibai Dihuang Pills
Trial Group B:Basic intervention + self-formulated marrow-sealing and alleviation formula
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Female
Age
4 Years to 7 Years
Inclusion criteria
Inclusion criteria: (1) Meets both Western medicine diagnostic criteria and Chinese medicine syndrome differentiation criteria; (2) 4 years = age = 7 years; (3) Duration = 6 months; (4) Has never received any related treatment before; (5) Written informed consent from the legal guardian.
Exclusion criteria
Exclusion criteria: (1) Previous history of breast development; (2) Confirmed diagnosis of central precocious puberty, peripheral precocious puberty, or localized breast proliferative disease; (3) Accompanied by other endocrine, cardiovascular, renal, hepatic, or hematopoietic system diseases; (4) History of drug allergy or allergic constitution; (5) History of exogenous estrogen intake or use of other medications within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The maximum diameter of breast tissue echo under B.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Breast Development Scoring;Follicle-Stimulating Hormone;Luteinizing Hormone;Estradiol; | — |
Countries
China
Contacts
Public ContactTingting Chen
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed