Sepsis-associated acute kidney injury
Conditions
Interventions
Intervention Group:Administer Qifu Huang formula via oral, gastric, or jejunal feeding tube, combined with standard treatment (including antibiotics and fluid resuscitation, etc.).
Placebo group:Administer placebo combined with standard therapy (including antibiotics and fluid resuscitation, etc.) via oral, gastric, or jejunal feeding tube routes.
Sponsors
Capital Medical University Affiliated Beijing Friendship Hospital Department of Critical Care Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years, meeting the diagnostic criteria for Sepsis-3.0; 2. Meeting the diagnostic criteria for KDIGO AKI; 3. Confirmed by a professional TCM physician through pattern identification to meet the criteria for using traditional Chinese herbal formulas; 4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with Chronic Kidney Disease (CKD Stage 4-5) (regular or irregular dialysis prior to ICU admission); patients with a history of kidney transplantation. 2. Patients allergic to the components of the study drug. 3. Patients who have clinically abandoned treatment or have been in the ICU for =7 days. 4. Patients where clinical judgment attributes irreversible kidney function to other factors (contrast agents, nephrotoxic drugs, urinary tract obstruction, etc.). 5. Patients suspected to have elevated Scr due to Angiotensin-Converting Enzyme Inhibitors (ACEI) or Angiotensin Receptor Blockers (ARB), with kidney function after discontinuation of ACEI/ARB. 6. Pregnant or breastfeeding women. 7. Patients participating in other drug clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal Function Recovery Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of days in ICU;Hospital Mortality Rate;28-day mortality rate;90-day mortality rate;Has renal function been restored after 90 days?; | — |
Countries
China
Contacts
Public ContactRan Pang
Capital Medical University Affiliated Beijing Friendship Hospital Department of Critical Care Medicine
Outcome results
None listed