Hashimoto's Thyroiditis
Conditions
Interventions
Treatment group:Jianpi Yishen Huatan Formula granules
Sponsors
Gansu Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Basic Information Requirements (1) Age: 18-65 years old; (2) Gender: No restriction. 2. Disease Diagnosis and Laboratory Indicators (1) Diagnostic Criteria: 1) Meeting the Western medicine diagnostic criteria for Hashimoto's Thyroiditis (HT); 2) Meeting the traditional Chinese medicine (TCM) syndrome differentiation criteria. (2) Key Biochemical Indicators: 1) Non-obese Body Mass Index (BMI) (18–30 kg/m²); 2) Abnormal results in at least three consecutive blood tests, with an interval of at least 3 months between the second and first tests; 3) No prior pharmacological treatment, relatively high serum Thyroid-Stimulating Hormone (TSH) levels, and positive Thyroid Peroxidase Antibody (TPOAb). (4) The sum of primary symptom scores is = 4 points, and the total syndrome score is = 8 points. 3. Voluntary participation and signing of the informed consent form, with a commitment to cooperate in completing the entire study period.
Exclusion criteria
Exclusion criteria: 1)Diagnosis or symptoms of other autoimmune diseases (e.g., type 1 diabetes, celiac disease, autoimmune gastritis, rheumatoid arthritis, or inflammatory bowel disease such as Crohn's disease and ulcerative colitis). 2)Use of any medications, including proton pump inhibitors, antibiotics, and probiotics/prebiotics, within the past 3 months or during the study period. 3)History of chronic diarrhea (=3 bowel movements per day for more than 4 weeks), chronic constipation ( 2 times the upper limit of normal), renal insufficiency (eGFR < 60 mL/min/1.73 m²), hematologic disorders, or psychiatric diseases. 7)Pregnancy, lactation, or plans to become pregnant within the next 6 month
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood Treg/Th17 ratio; | — |
Secondary
| Measure | Time frame |
|---|---|
| TPOAb;Microbiota Diversity;SCFAs; | — |
Countries
China
Contacts
Public ContactZhou Zubang
Gansu Provincial Hospital
Outcome results
None listed