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Clinical efficacy evaluation and metabolomics study of electroacupuncture combined with three-step pain relief therapy in the treatment of moderate to severe pain in hepatocellular carcinoma

Clinical efficacy evaluation and metabolomics study of electroacupuncture combined with three-step pain relief therapy in the treatment of moderate to severe pain in hepatocellular carcinoma

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026000875
Enrollment
Unknown
Registered
2026-04-02
Start date
2026-04-20
Completion date
Unknown
Last updated
2026-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

Observation group:Basic treatment + Electroacupuncture treatment

Sponsors

Yueyang Integrated traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients who meet the diagnostic criteria for hepatocellular carcinoma; (2) Age =40 years old and =80 years old, gender not limited; (3) Patients with Child-Pugh grade A or B; (4) The NRS score is =4 points within 24 hours before screening; (5) Patients with an expected survival period of more than 3 months; (6) Clear consciousness, capable of assessing one's own pain and quality of life; (7) Those who understand and agree to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with other physiological or pathological pain; (2) Patients who have undergone tumor resection within the past 3 to 6 months; (3) Patients with severe complications such as persistent ascites, abdominal infection, gastrointestinal bleeding, liver failure, and abdominal bleeding; (4) Patients suffering from severe acute or chronic organ diseases or mental disorders; (5) Patients with contraindications to electroacupuncture, such as those with local skin damage, those who are particularly sensitive to electric current, those with pacemakers or cardiovascular stents; (6) Women patients who are pregnant, lactating or planning to conceive in the near future; (7) Patients who have previously received electroacupuncture treatment; (8) Patients who are scheduled for surgery within the last 28 days.

Design outcomes

Primary

MeasureTime frame
Effective rate of pain relief;

Secondary

MeasureTime frame
Assessment of pain degree;Number of bursts of pain;Analgesic dosage;Frequency of gastrointestinal side effects;Comprehensive evaluation of life quality;Fatigue degree assessment;Sleep conditions assessment;Biochemical detection;Metabolomics detection;

Countries

China

Contacts

Public ContactWu Huangan

Shanghai Research Institute of Acupuncture and Meridian

wuhuangan@126.com13601611239

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: May 1, 2026