Alzheimer's Disease
Conditions
Interventions
Study Group:Assist the patient in sitting position with arms naturally hanging down and hands placed on the thighs. Guide the patient to relax all muscles. Select the acupoints Baihui (GV20), Yintang
after one month, the dose may be increased to 10 mg/day based on specific circumstances.
Control group:Assist the patient to sit with arms naturally hanging down and hands placed on the thighs. Guide the patient to relax all muscles. Select points 1 cm beside Baihui (GV20), Yintang (GV29)
after one month, the dosage may be increased to 10 mg/day based on specific circumstances.
Sponsors
Tongde Hospital of Zhejiang Province
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Inclusion criteria for study subjects: aged 60-75 years; education level above junior high school; right-handed; meeting the criteria of the revised Alzheimer's Disease Diagnostic and Staging Standards (2024 edition) established by the National Institute on Aging-Alzheimer's Association (NIA-AA); positive plasma p-tau217; MMSE score =15; CDR score = 1-2; HIS (Hachinski score) =4; signed informed consent form.
Exclusion criteria
Exclusion criteria: The individual has unstable diabetes, obstructive pulmonary disease, or asthma; a history of bleeding disorders or malignancy within the past 2 years, hypothyroidism, vitamin B or folate deficiency; conclusive clinical evidence of active gastrointestinal, renal, hepatic, endocrine, or cardiovascular disease, bradycardia, or sick sinus syndrome; other neurological or psychiatric conditions, such as Parkinson's disease, stroke, epilepsy, bipolar or unipolar depression, schizophrenia; a history of loss of consciousness due to traumatic brain injury or a modified Hachinski score =4; known or suspected alcohol or substance abuse within the past decade; or abnormal visual or auditory function that cannot be corrected to enable normal functioning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scale Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Diffusion Tensor Imaging; | — |
Countries
China
Contacts
Public ContactLijuan Wang
Tongde Hospital of Zhejiang Province
Outcome results
None listed