Acute gastrointestinal injury in sepsis
Conditions
Interventions
Observation group:Dachengqi Decoction combined with conventional Western medical treatment
Sponsors
Hefei Third People's Hospital
Eligibility
Sex/Gender
All
Age
19 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1) Meets diagnostic criteria for sepsis and II-III grade SAGI; 2) Age 18 years; 3) Chinese medical pattern identification: Gastrointestinal Heat Stagnation Syndrome. Primary symptoms: high fever with shortness of breath, abdominal distension and (bloating), hard stools, inability to pass gas. Secondary symptoms: restlessness, delirious speech or even (delirium), halitosis, thirst, sweating of palms and soles, dark yellow urine. Tongue and pulse: red tongue with yellow and dry coating, deep-string or fine-rapid pulse.
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years old; 2. Hospitalization duration less than 7 days; 3. Women in pregnancy or lactation; 4. Patients with malignant tumors, severe liver disease, hematological disorders, or immunodeficiency diseases; 5. Allergic to any component of Dachengqi Decoction; 6. Use of gastrointestinal motility drugs within the past two weeks; 7. Incomplete clinical data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-abdominal pressure;Gastrointestinal Function Scoring;Efficient;28-day mortality rate;Intestinal Wall Tissue Pathology Scoring;Citrulline, D-lactic acid, and inflammatory factors; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraperitoneal infusion pressure;Enteral nutrition tolerance;First bowel movement time;Mechanical Ventilation Duration;Hospitalization Duration;Procalcitonin (PCT), Interleukin-6 (IL-6), C-reactive protein (CRP);Acute Physiology and Chronic Health Evaluation;Intestinal wall blood flow; | — |
Countries
China
Contacts
Public ContactWu Daorong
Hefei Third People's Hospital
Outcome results
None listed