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Exploring Neurological Functional Impairment and Prognostic Mechanisms in Patients with Acute Ischemic Stroke (AIS) Based on Multimodal Neuroassessment.

Pathogenesis and Predictive Models of Neurological Functional Impairment in Acute Ischemic Stroke (AIS)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2026000783
Enrollment
Unknown
Registered
2026-03-27
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Stroke

Interventions

Patients with acute ischemic stroke (AIS):Non-intervention

Sponsors

Shanghai University of Traditional Chinese Medicine Affiliated Yueyang Integrated Chinese and Western Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Meets the diagnostic criteria for ischemic stroke, first-time onset, and time from onset to enrollment does not exceed 14 days; (2) No gender restrictions, age between 18 and 80 years inclusive; (3) First-time stroke or previous stroke did not result in significant disability (mRS 0 points); (4) Understands, agrees to participate in this study, and signs the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with cerebral hemorrhage, neurodegenerative diseases, neurological infections, or neurological tumors; (2) Patients who undergo cerebral vascular interventional therapy after admission; (3) Patients classified as "other confirmed etiology" according to the TOAST criteria; (4) Patients with mental illness who are unable to cooperate; (5) Patients with absolute contraindications for near-infrared spectroscopy, cranial magnetic resonance imaging, or electroencephalography, such as those with implanted cardiac pacemakers; (6) Patients who are breastfeeding or of childbearing age.

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Assessment;—

Secondary

MeasureTime frame
Modified Rankin Scale;Brunnstrom Stroke Recovery Stage Scale;Skull MR plain scan + Skull MRI arterial spin labeling (ASL);National Institutes of Health Stroke Scale (NIHSS);Dynamic Blood Pressure;Carotid Ultrasound;Mini-Mental State Examination Scale;Montreal Cognitive Assessment Scale;Patient Health Questionnaire-9(PHQ-9);Generalized Anxiety Disorder 7-item scale(GAD-7);Fatigue Severity Scale;Visual Analog Scale;Barthel Index;Activities of Daily Living(ADL);Athens Insomnia Scale;Criteria for Pattern Identification of Stroke;Traditional Chinese Medicine Symptom Grading Scale;Traditional Chinese Medicine Constitution Scale;Cranial Diffusion Tensor Imaging;Carotid Computed Tomography Angiography;Cranial Computed Tomography Perfusion;Functional near-infrared spectroscopy;Quantitative Electroencephalography;electromyography;C-reactive protein;Tumor Necrosis Factor-alpha;Interleukin;Total Cholesterol;Triglyceride;Low-density lipoprotein cholesterol;High-density lipoprotein cholesterol;Cystatin C;N-terminal pro-brain natriuretic peptide;Serum homocysteine;Neuron-specific enolase;Blood Routine;Urinalysis;Stool Routine;Liver Function;renal function;Fasting Blood Glucose;glycated hemoglobin;Electrolyte;Coagulation function;—

Countries

China

Contacts

Public ContactZhang Yunyun

Shanghai University of Traditional Chinese Medicine Affiliated Yueyang Integrated Chinese and Western Medicine Hospital

zhangyyun@hotmail.com13816134690

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: May 1, 2026