intrapartum fever durring labor analgesia
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) ASA Physical Status Class I-II (2) Age 18-40 years (3) Body mass index (BMI) <30 kg/m² (4) Gestational age =37 weeks (5) Primiparous women with singleton cephalic presentation (6) Request for epidural analgesia at cervical dilation =3 cm (7) Afebrile status (=37.2°C) upon labor room admission and no febrile history within one week (8) Absence of contraindications to epidural anesthesia (9) Without hypertensive disorders of pregnancy (10) Normal fetal heart rate monitoring prior to analgesia (120-160 bpm)
Exclusion criteria
Exclusion criteria: (1) Cephalopelvic disproportion or pelvic deformities (2) Cervical dilation >3 cm at the time of labor analgesia request (3) Contraindications to neuraxial anesthesia (e.g. coagulopathy local infection at puncture site) (4) Opioid or other sedative/analgesic use within one week (5) Current magnesium sulfate administration (6) History of substance abuse (7) Severe cardiopulmonary/hepatic/renal dysfunction (8) Active infection within two weeks or recent antibiotic use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| maternal intrapartum fever incidence rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal temperature ;pain NRS score;analgesic consumption and number of effective PCEA demands;duration and method of membrane rupture;number of vaginal examinations;Obstetric outcome;Neonatal outcome;Concentrations of inflammatory factors (IL-6, IL-1ß, and TNF-a); | — |
Countries
China
Contacts
Women's Hospital of Nanjing Medical University