gout
Conditions
Interventions
experimental group:febuxostat+Luohuazizhu tablet
Sponsors
Shenzhen City Luohu District Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Aged 18–65 years; 2) Hyperuricemia (male sUA > 420 µmol/L, female sUA > 360 µmol/L) or gout in remission (no acute flare in the past 4 weeks); 3) Signed informed consent and willingness to comply with the study protocol.
Exclusion criteria
Exclusion criteria: Severe hepatic/renal insufficiency; Other systemic inflammatory diseases; Use of antibiotics or probiotic supplements within the past 4 weeks; Pregnancy/lactation; Deemed by the investigator to be unsuitable for enrollment. 5) Those who are allergic to the study drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| uric acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function: ALT, AST; Renal function: Scr, BUN, eGFR; Blood lipids: TC, TG, HDL-C, LDL-C; Urinary indicators: Urine pH, Urine uric acid; Gut microbiota: a/ß diversity, differential microbiota, functional pathways.; | — |
Countries
China
Contacts
Public ContactYuewen Zheng
Luohu Hospital of Traditional Chinese Medicine
Outcome results
None listed