Chronic Fatigue Syndrome
Conditions
Interventions
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for CFS Subjects (1) Meets the CFS diagnostic consensus established by NICE in 2021; (2) Meets the DSQ-PEM scoring criteria for post-exertional malaise diagnosis; (3) Aged between 20-60 years, with no gender restrictions; (4) No abnormalities found in routine blood and urine tests, and liver and kidney function; (5) Right-handed; (6) Agrees and signs the informed consent form. Inclusion Criteria for Healthy Subjects (1) No history of CFS; (2) Aged between 20-60 years, with no gender restrictions; (3) No abnormalities found in routine blood and urine tests, and liver and kidney function; (4) Agrees to maintain a regular schedule during the study and avoid activities that may lead to fatigue.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for CFS Subjects (1) Recent history of panic attacks within the past 6 months; (2) Diagnosis of schizophrenia, major depressive disorder, bipolar affective disorder, or anxiety disorders (e.g., obsessive-compulsive disorder or post-traumatic stress disorder); (3) Hospitalization for psychological issues within the past 6 months; (4) Excessive alcohol consumption; (5) Smokers or those who have quit smoking for less than 1 year; (6) Diabetes; (7) Orthopedic restrictions prohibiting physical activity; (8) Pregnancy or breastfeeding. Exclusion Criteria for Healthy Subjects (1) Abnormal results in routine blood or urine tests, or liver and kidney function tests; (2) Presence of endocrine system diseases, musculoskeletal diseases, autoimmune diseases, infectious diseases, diabetes, or other metabolic diseases, or mental disorders; (3) Participants who do not comply with the arrangements related to this study during the trial period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chalder Fatigue Questionnaire(CFQ-11); | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index (PSQI);Medical Outcomes Study Short Form 12-Item (SF-12);Work and Social Adjustment Scale(WSAS);DePaul Post-Exertional Malaise Questionnaire;Clinical Global Impressions Scale (CGI);Depression-Anxiety-Stress Scale (DASS-21);Brief Pain Inventory (BPI);International Physical Activity Questionnaire (IPAQ);Grip strength;Cardiopulmonary Exercise Testing (CPET);Near-Infrared Spectroscopy (NIRS);Magnetic Resonance Spectroscopy (MRS);electromyography;Electroencephalogram;venous blood; | — |
Countries
China
Contacts
Public ContactWen Zong Lin
Shanghai University of Traditional Chinese Medicine
Outcome results
None listed