Chronic Gouty Arthritis
Conditions
Interventions
Experimental Group:Huazhuo Sanjie Chubi Granule, 1 sachet each time, twice a day, for 8 consecutive weeks.
Control Group:Traditional Chinese Medicine granule placebo (containing 10% Huazhuo Sanjie Chubi Granule per sachet)
Sponsors
Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years old. Meet the above Western medicine diagnostic criteria for CGA. 2.Meet the above TCM diagnostic criteria for the 3.syndrome of spleen deficiency, damp-heat, phlegm-turbidity and blood stasis obstruction. 4.Serum IL-1ß inflammatory factor is 2 to 3 times higher than the normal value (indicating persistent low-grade inflammation). 5.No acute gout attack in the past 1 month. 6.No antibiotics, glucocorticoids, non-steroidal anti-inflammatory drugs or other medications that may affect the observation of this trial have been taken in the 2 weeks before enrollment. 7.No other mental illnesses, and able to cooperate with the researchers. 8.No acute infections of the respiratory, circulatory, digestive or urinary systems in the past 1 month. 9.Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Complicated with other types of arthritis (e.g., rheumatoid arthritis, osteoarthritis, psoriatic arthritis, ankylosing spondylitis, systemic lupus erythematosus, infectious arthritis, etc.). 2.Secondary gout caused by tumor radiotherapy/chemotherapy, hematological diseases, or medications. 3.History of major trauma or surgery within the past 1 month. 4.Currently receiving immunosuppressant therapy. 5.Severe hearing or visual impairment that prevents cooperation with the investigators. 6.Acute or chronic hepatic/renal insufficiency, or malignant tumors. 7.Allergic to the medications involved in the study protocol, or with contraindications to their use. 8.Pregnant or lactating. 9.History of chronic diseases such as diabetes, hypertension, coronary heart disease, asthma, or chronic obstructive pulmonary disease. 10.Individuals deemed ineligible for this clinical trial by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Low-grade inflammation-related indicators in serum; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Uric Acid;erythrocyte sedimentation rate;C-reactive protein;Liver and kidney function;Routine Urine Test;Blood Routine Test;Blood lipid;Blood glucose;Traditional Chinese Medicine Syndrome Score;Joint Swelling and Pain Likert Scale Score;Visual Analogue Pain Score;Gout Impact Scale;Health Assessment Questionnaire Disability Index; | — |
Countries
China
Contacts
Public ContactSu Youxin
Fujian University of Traditional Chinese Medicine
Outcome results
None listed