Subclinical atherosclerosis
Conditions
Interventions
Experimental group:Guizhi Tongluo tablets
Control group:Guizhi Tongluo tablets placebo
Sponsors
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Eligibility
Sex/Gender
All
Age
35 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for carotid atherosclerosis 2.Aged 35 years = Age < 65years 3.Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.History of cardiovascular disease (including myocardial infarction, or treatment with percutaneous coronary intervention [PCI] or coronary artery bypass grafting [CABG]); 2.Have a history of stroke (including atherosclerotic cerebral infarction or hemorrhagic stroke, but lacunar infarction and transient ischemic attack [TIA] are not excluded); 3.Diseases of secondary hypertension, including renal parenchymal or renal vascular diseases, primary aldosteronism, pheochromocytoma, hyperthyroidism, etc; However, the patient has no clinical signs or symptoms in one or more arterial regions or atherosclerosis diseases that can be attributed to the clinical manifestations in this region, such as angina, stroke, limb pain, etc; 4.Severe liver, kidney and other organ dysfunction (ALT = 3 times the upper limit of normal); Subjects undergoing dialysis treatment; Or blood creatinine>2.5 mg/dl [>221 mol/L]; 5.Severe acute or chronic infections, immune system diseases, hematopoietic or coagulation dysfunction; Merge other serious illnesses and have an expected life expectancy of less than 12 months; 6.Pregnancy or breastfeeding; 7.Participants in other clinical research trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plaque neovascularization score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Carotid intima-media thickness;Size and area of carotid plaque;Echoes of carotid plaques;Chinese Medicine Blood Stasis Syndrome Efficacy Score;Quality of Life and Sleep Quality;Biochemical indicators of cardiovascular risk factors;Number of plaques;Carotid artery stenosis and severity assessment;Carotid artery blood flow velocity (PSV);plaque morphology;Baseline indicators; | — |
Countries
The People's Republic of China
Contacts
Public ContactHaibing Rao
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Outcome results
None listed