Adolescent Depression
Conditions
Interventions
Liver Qi Stagnation Syndrome Group of aMDD:Traditional Chinese medicine preparation: Chaihu Shugan Wan
Heart-spleen deficiency syndrome Group of aMDD:Traditional Chinese Medicine preparation: Ginseng Gui Pi Pills
Sponsors
Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: aMDD Group Inclusion Criteria: 1) Age 12–18 years; 2) Meets DSM-5-TR criteria for Major Depressive Disorder (MDD); 3) Episode severity rated as mild or moderate; 4) Hamilton Depression Rating Scale (HAM-D) score >17 (mild: 8–16 points; moderate depression: 17–23 points); 5) Meets TCM diagnostic criteria for Liver Qi Stagnation Pattern or Heart-Spleen Deficiency Pattern; 6) No antidepressant or other psychiatric medication use within 2 months prior to enrollment, or discontinuation for =2 months; 7) Voluntary participation by the subject with informed consent signed by a legal guardian. Healthy Control Group Inclusion Criteria: 1) Meets criteria for the "Harmonious Constitution" classification in the "Classification and Determination of Traditional Chinese Medicine Constitutions," with a conversion score =60 on the "Traditional Chinese Medicine Constitution Classification and Determination Table," and conversion scores for all other 8 constitutions <30; 2) Does not meet diagnostic criteria for any depressive disorder, bipolar disorder, psychotic disorder, or other mental disorders in DSM-5-TR; 3) No past or current history of mental disorders such as depression or anxiety; no first-degree relatives with a history of major mental disorders (e.g., schizophrenia, bipolar disorder); 4) HAM-A < 7, HAM-D < 7; 5) Matched with aMDD group subjects in terms of gender, age, and educational level; 6) No use of any antidepressants, antipsychotics, or centrally acting medications within the past 2 months; 7) Subjects voluntarily participate, with informed consent signed by legal guardians.
Exclusion criteria
Exclusion criteria: aMDD Group Exclusion Criteria: 1) Organic brain disease. 2) Depression associated with medically induced or substance-induced depressive symptoms. 3) Seasonal depressive pattern as defined by DSM-5-TR. 4) Bipolar disorder, psychotic disorders, personality disorders, pervasive developmental disorders, autism spectrum disorders, obsessive-compulsive disorder, post-traumatic stress disorder, attention-deficit/hyperactivity disorder, or eating disorders and other psychiatric disorders. 5) History of bipolar I/II disorder in first-degree relatives. 6) Suicide risk indicated by explicit intent and plans and/or prior suicide attempts. 7) History of neurological disorders, seizures, substance abuse, or alcohol dependence within the past year. 8) Severe cardiac, hepatic, renal, or hematologic diseases; uncontrolled hyperthyroidism or hypothyroidism. Healthy control group exclusion criteria: 1) Past or current clinical diagnosis of any psychiatric disorder, including depression, anxiety, bipolar disorder, schizophrenia, obsessive-compulsive disorder, or attention deficit hyperactivity disorder. 2) Organic brain disorders (e.g., traumatic brain injury, brain tumor, intracranial infection, cerebrovascular disease). 3) Severe cardiac, hepatic, renal, or hematologic diseases; uncontrolled hyperthyroidism or hypothyroidism. 4) History of neurological disorders, epileptic seizures, psychoactive substance abuse, or alcohol dependence within the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale(HAMD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Traditional Chinese medicine Syndrome Score;Electroencephalogram(EEG) behavioral data;Electroencephalogram(EEG) data; | — |
Countries
China
Contacts
Public ContactRui Xu
Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical Sciences
Outcome results
None listed