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A Study Protocol on the Impact of Huangqin Decoction on Gut Microbiota and Autophagy in Patients with Sepsis-Related ARDS Based on the Gut-Lung Axis

A Study Protocol on the Impact of Huangqin Decoction on Gut Microbiota and Autophagy in Patients with Sepsis-Related ARDS Based on the Gut-Lung Axis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026000699
Enrollment
Unknown
Registered
2026-03-24
Start date
2024-09-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Lung Injury

Interventions

Treatment group:Conventional Western medical treatment plus Huangqin Decoction

Sponsors

Shanghai City Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients who meet the diagnostic criteria for sepsis-related ARDS in Western medicine and the criteria for disease differentiation and syndrome differentiation in traditional Chinese medicine, and voluntarily agree to participate in the treatment plan of this study. (2) Age >18 years, gender. (3) The informed consent process complies with regulations, and the patient agrees to participate in this study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Age < 18 years; (2) Patients in the terminal stage of chronic diseases; patients with mental abnormalities; (3) Patients with malignant tumors, severe hepatic or renal dysfunction (cirrhosis, acute or chronic hepatitis, glomerulonephritis, nephrotic syndrome), active bleeding, thrombotic diseases (acute myocardial infarction, pulmonary embolism, acute cerebral infarction), or severe burns; (4) Patients with allergies to multiple drugs or allergic constitutions; (5) Patients currently participating in other clinical trials; (6) Patients with incomplete clinical data, imaging, or follow-up records; (7) Patients with low compliance. If any of the above answers is "yes," the patient cannot be enrolled.

Design outcomes

Primary

MeasureTime frame
Respiratory function index;Circulatory Perfusion Index;Inflammatory markers;Autophagy-related proteins;gut microbiota;

Secondary

MeasureTime frame
APACHE II score;SOFA Score;Murray Lung Injury Score;Traditional Chinese Medicine Syndrome Scoring;

Countries

China

Contacts

Public ContactMai Jing Yin

Shanghai Municipal Hospital of Traditional Chinese Medicine

maijingyin@126.com13681883155

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Apr 4, 2026