Sarcopenia with Knee Osteoarthritis
Conditions
Interventions
Conventional Western medicine treatment group:Conventional Western medicine treatment group
Chinese herbal medicine exposure group:Jianpi Qiangji Granules
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria for sarcopenia; 2) Age: 50–85 years; 3) Meet the diagnostic criteria for knee osteoarthritis; 4) Baseline nutritional status: Mini Nutritional Assessment Short-Form (MNA-SF) score=8 (indicating no risk of malnutrition or low risk of malnutrition); 5) Voluntarily participate in the trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Individuals meeting any of the following criteria will not be included in this trial:Severe malnutrition (defined as: MNA-SF score = 7, or as comprehensively assessed by a clinician/nutritionist); Patients with advanced chronic consumptive diseases, such as advanced malignant tumors, chronic obstructive pulmonary disease (COPD), severe chronic kidney disease (eGFR<30 and above), severe diabetes, or other diseases or physiological conditions that could affect muscle mass; Patients with acute loss of mobility, such as reduced mobility due to various fractures, especially after hip fracture; Severely obese individuals; Patients with neuromuscular diseases, such as Parkinson's disease; Individuals positive for Hepatitis B surface antigen, Hepatitis C antibody, or HIV antibody; Patients with mental illness; Individuals with hearing or visual impairments that interfere with communication or daily activities; Individuals with cognitive impairment; Regular use of medications potentially used to treat sarcopenia or tuina therapy within the 3 months prior to enrollment, such as calcium supplements, vitamin D and its analogs (e.g., calcitriol), androgens (testosterone, dehydrotestosterone, dihydrotestosterone, etc.), growth hormone (insulin-like growth factor, etc.); History of drug or alcohol abuse within the past year; Any subject judged by the investigator as having a reduced likelihood of enrollment (e.g., frail, etc.), a tendency towards non-compliance during the study period, or other conditions that complicate enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Calf circumference change value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle strength;Pain ;Physical fitness;Screening and Nutrition;Scales and Quality of Life;Related to Traditional Chinese Medicine;Imaging (or Radiology);Body composition; | — |
Countries
China
Contacts
Public ContactFang Min
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed