Diabetic lower extremity vascular lesions
Conditions
Interventions
Treatment group:The basic Western medicine is combined with clopidogrel bisulfate tablets 75mg every day, and 4 capsules of Tangbi are taken orally three times a day
Control group:Basic Western medicine combined with clopidogrel bisulfate tablets 75mgqd
Blank group:Basic treatments such as lowering blood sugar in Western medicine
Sponsors
Department of Endocrinology, University Town Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with lower extremity vascular lesions in type 2 diabetes. (2) Patients who are diagnosed as having symptoms of qi deficiency and blood stasis, or damp-heat and blood stasis obstruction in traditional Chinese medicine. (3) Age between 18 and 80 years old, gender not limited. (4) Voluntarily participate in this trial and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with moderate to severe edema of the lower extremities or suffering from lower extremity skin diseases; (2) Patients with acute complications such as diabetic ketoacidosis, hyperglycemic hyperosmolar syndrome, diabetic lactic acidosis, and acute gout; (3) Those with Yin deficiency syndrome in traditional Chinese medicine; (4) Those with cancer or failure of organs such as the heart, liver and kidneys; (5) Pregnant or lactating individuals, or those who have planned to get pregnant within the past year; (6) Participated in other clinical researchers within the past three months; (7) Patients who cannot understand the nature, scope and possible results of the research, or who cannot follow the doctor's advice; (8) People with mental illness, those with allergic constitutions, and those with a history of drug, food or contact allergies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Shear stress of the lower extremity arterial wall; | — |
Secondary
| Measure | Time frame |
|---|---|
| VEGF;ET-1;IL-6;CRP;NO;Hemodynamic indicators;sICAM-1;sVCAM-1;vWF;Blood metabolomics, transcriptomics;ABI; | — |
Countries
China
Contacts
Public ContactWei Song
Department of Endocrinology, University Town Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed