diminished ovarian reserve
Conditions
Interventions
experimental group:Integration of traditional Chinese and Western medicine
control group:Western medicine
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
22 Years to 39 Years
Inclusion criteria
Inclusion criteria: 1: Female patients aged 22 to 39 years (inclusive). 2: Meeting the Western medicine diagnostic criteria for Diminished Ovarian Reserve (DOR) and infertility. 3: Meeting the Traditional Chinese Medicine (TCM) diagnostic criteria for kidney deficiency syndrome 4: Voluntarily participating in the study and having provided written informed consent.
Exclusion criteria
Exclusion criteria: 1: Patients with organic pathologies such as premature ovarian insufficiency or premature ovarian failure (basal FSH >25 IU/L), ovarian tumors, endometrial tuberculosis, intrauterine adhesions, or endometrial injuries, as well as those with congenital adrenal hyperplasia or Cushing's syndrome; 2: Exclusion of infertility caused by organic lesions of the fallopian tubes, uterus, cervix, etc. 3: Infertility due to male factors (based on semen analysis reports, meeting the diagnostic criteria for oligoasthenoteratozoospermia according to the WHO 5th edition standards). 4: Exclusion of DOR caused by iatrogenic factors (such as pelvic surgery, radiotherapy/chemotherapy, uterine artery embolization, etc.). 5: Patients with impaired liver and kidney function or severe primary diseases of the cardiovascular, cerebrovascular, or hematopoietic systems, or psychiatric disorders. 6: Individuals with known allergies to the investigational drug or its components. 7: Use of hormonal medications (e.g., estrogen, contraceptive drugs) within one month prior to enrollment, or use of kidney-tonifying Chinese herbal medicines or proprietary Chinese medicinal products within one month prior to enrollment. 8: Patients currently participating in or planning to participate in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serological indicators related to ovarian reserve function (AMH, FSH);antral follicular count;Traditional Chinese Medicine syndrome scoring;ovulation rate;Biological pregnancy rate; | — |
Countries
China
Contacts
Public ContactSun Aijun
Peking Union Medical College Hospital
Outcome results
None listed