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Effect of Wumei-Gancao Spray Based on the "Acid-Sweet Combination for Nourishing Yin" Theory on Xerostomia in Terminal Cancer Patients: A Clinical Study

Effect of Wumei-Gancao Spray Based on the "Acid-Sweet Combination for Nourishing Yin" Theory on Xerostomia in Terminal Cancer Patients: A Clinical Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026000645
Enrollment
Unknown
Registered
2026-03-20
Start date
2025-06-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Terminal Cancer

Interventions

Intervention Group:In the first cycle, participants used the Wumei-Gancao Spray for 6 days. This was followed by a 1-day washout period using normal saline spray. Subsequently, in the second cycle, pa
Control Group:In the first cycle, participants used the lemon-flavored water spray for 6 days. This was followed by a 1-day washout period using normal saline spray. Subsequently, in the second cycle,

Sponsors

The First Affiliated Hospital of Zhejiang Chinese Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1)Pathologically diagnosed with malignant cancer and an estimated life expectancy of less than 6 months. 2)Presence of thirst symptoms with a Visual Analog Scale (VAS) score = 5. 3)Absence of oral mucosal pathologies such as congestion, edema, erosion, or ulceration. 4)Aged 18 years or older. 5)Provided written informed consent from the patient or their legally authorized representative.

Exclusion criteria

Exclusion criteria: 1)Development of impaired consciousness or any other condition that precluded cooperation with the study procedures during the treatment period. 2)Intolerance or significant adverse reactions to the intervention. 3)Failure to complete the trial protocol as required, leading to unevaluable outcome data. 4)Inability to receive oral spray administration or to undergo saliva collection.

Design outcomes

Primary

MeasureTime frame
Summated Xerostomia Inventory,SXI;Unstimulated Whole Saliva Flow Rate (UWSFR);

Countries

CHINA

Contacts

Public ContactBaiNv Wu

The First Affiliated Hospital of Zhejiang Chinese Medical University

wubainv@163.com13777592704

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Apr 4, 2026