Knee osteoarthritis
Conditions
Interventions
Healthy group:None
Sponsors
Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria for KOA Subjects (1) Age 40-70 years, gender; (2) Meet the diagnostic criteria for KOA; (3) Agree to undergo gait collection, lower limb X-ray imaging, and other examinations; (4) BMI < 28; (5) K-L grading: I-III; (6) Unilateral knee osteoarthritis; (7) Patients voluntarily participate and sign the informed consent form. Inclusion Criteria for Healthy Subjects (1) Age 40-70 years, gender; (2) Agree to undergo gait collection, lower limb X-ray imaging, and other examinations; (3) BMI < 28; (4) Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for KOA Subjects (1) Patients in the acute episode of KOA (reference to "Chinese Guidelines for Diagnosis and Treatment of Knee Osteoarthritis (2020 Edition)": knee pain (VAS score >7), or persistent pain, severe pain making it difficult to sleep; knee swelling, functional impairment, limping or inability to walk); (2) Patients with severe cognitive impairment or mental illness affecting the assessment of indicators; (3) Patients with other diseases such as rheumatoid arthritis, gout, or osteoporosis; (4) Patients with a history of joint cavity injection or surgical operation within the past month; (5) Patients in pregnancy or lactation; (6) Patients with other diseases affecting normal lower limb movement and gait. Exclusion Criteria for Healthy Subjects (1) Patients with other diseases significantly affecting normal walking status, such as Parkinson's syndrome, post-stroke sequelae, or spinal stenosis; (2) Patients with severe cardiovascular, cerebrovascular, liver, kidney, or hematological diseases, or cognitive impairment and mental illness; (3) Patients with other diseases such as rheumatoid arthritis, gout, or osteoporosis; (4) Patients with a history of joint cavity injection or surgical operation within the past month; (5) Patients in pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait myoelectric indices (root mean square (RMS), median frequency (MF), integrated electromyography (iEMG), activation time of lower limb muscle groups during stance phase, co-activation ratio of muscle groups around the knee joint, etc., including quadriceps femoris, hamstrings, tibialis anterior, gastrocnemius, etc.);Full-length standing X-ray of the lower extremity, force line-related angles: Hip-Knee-Ankle Angle (HKA), Mechanical Axis Distal Femoral Lateral Angle (mMPTA), Distal Femoral Lateral Angle (LDFA), Joint Line Convergence Angle (JLCA).;Gait kinetic indices (e.g., joint three-dimensional torque peaks); | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Cartilage Oligomeric Matrix Protein (COMP), Type II Collagen Alpha-1 Chain (COL2A1), SRY-Related High Mobility Group Box Gene 9 (SOX9);Serum bone metabolism indicators: Alkaline Phosphatase (ALP), Receptor Activator of Nuclear Factor ?B Ligand (RANKL), Osteoprotegerin (OPG), Runt-related transcription factor 2 (RUNX2).;Gait kinematics selected indices (such as joint three-dimensional angle peak values);Finite Element Analysis of Meniscus, Ligaments, Tendons, Tibiofemoral Cartilage, and Subchondral Bone Stress Distribution or Elastic Modulus;Superficial Quadriceps Femoris Angle; | — |
Countries
China
Contacts
Public ContactZheng Zhuo Ming
Fujian University of Traditional Chinese Medicine, First Clinical College
Outcome results
None listed