The aging condition of middle-aged and elderly people
Conditions
Interventions
Low-frequency Taijiquan group:Taijiquan, 60 minutes each time, once a week.
blank control group:The blank control group maintained their daily lifestyle without any regular exercise intervention.
Regular exercise group:Aerobic exercise
Sponsors
School of Physical Education and Sports, Beijing Normal University
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Middle-aged and elderly people aged between 45 and 80 years old; (2) Those who have signed the informed consent form and can complete the entire experimental process; (3) No implanted objects in the body (such as metal or heart stents); (4) Independent in daily life and free from diseases that affect the ability to move (such as after arthroscopic surgery, angina pectoris, stroke, etc.).
Exclusion criteria
Exclusion criteria: (1) Patients with secondary hypertension (hypertension caused by other diseases or clear etiologies), cardiomyopathy, arrhythmia, and heart failure; (2) Patients who have suffered from acute myocardial infarction, cerebrovascular accident, uncontrolled heart failure, severe trauma or major surgery within the past six months; (3) Patients with severe primary diseases of the liver, kidneys, etc. or malignant tumors; (4) Patients diagnosed with various acute infectious diseases, such as pulmonary infection, viral hepatitis, mumps, urinary tract infection, etc., and acute coronary syndrome; (5) Patients with severe peripheral vascular diseases (such as carotid artery stenosis, arterial embolism, aneurysm, etc. requiring interventional treatment), severe coronary heart disease, pulmonary heart disease, severe cerebral infarction, respiratory failure, autoimmune diseases (such as systemic lupus erythematosus, rheumatoid arthritis, scleroderma, etc.), thromboangiitis obliterans, etc.; (6) Patients with severe mobility impairments (chronic or severe pain preventing physical activity), obvious lower limb joint injuries or musculoskeletal diseases (such as severe arthritis) that impair walking or prevent completion of the test; (7) Patients with mental illness, dementia, Parkinson's syndrome, epilepsy, severe neurosis, etc., including those who cannot judge the therapeutic effect, accurately provide their condition or cooperate; (8) Patients who have participated in similar exercise intervention experiments within the past six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aging Markers of the Skeletal System;Bone Mineral Density;Biomarkers of Skeletal Aging;Bone formation markers;Bone resorption markers;Vascular aging indicators;Brachial-ankle pulse wave velocity;Ankle-brachial index;Biomarkers of vascular aging;Muscle Aging Biomarkers;Skeletal Muscle Mass;Muscle Function Biomarkers;Neuromuscular Control;Muscle aging biomarkers;Biomarkers of Brain Aging;Biomarkers of Brain Function;Brain Imaging Biomarkers;Serum Biomarkers of Brain Aging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hormonal Biomarkers;Urinary biomarkers;Motor Function;Aging-Associated Questionnaires;Depression Scale;Anxiety Scale;Quality of Life Scale;Pittsburgh Sleep Quality Index ;International Physical Activity Questionnaire ;Mini Nutritional Assessment;Quality of Life Questionnaire for Lower Extremity Arteriosclerosis Obliterans;Perceived Stress Scale;Cognitive scale;Vascular Aging-Associated Questionnaire;Musculoskeletal Aging Questionnaire;Brain Aging Questionnaire;Neural Aging Questionnaire;Seattle Angina Questionnaire;Profile of Mood States;Exercise-Induced Affect Scale;Inflammation-related Biomarkers;Oxidative Stress-Related Biomarkers;Muscle Physical Properties;Epigenetic Regulation;Calcium Ions and Their Regulatory Proteins;Vascular Endothelial Function-Related Biomarkers;Quantitative Detection of Sensory and Motor Nerves;Cerebral Oxygenation Parameters;Neuroendocrine Biomarkers;Neurotransmitters;Kinematic and Kinetic Parameters;MicroRNA;Extracellular Matrix Proteins ;Intestinal Microbiota Taxonomic Classification and Functional Sequencing Metrics;Biomarkers Related to Metabolic Products;Marked Stepping Test;Heart Rate Variability;Balance ability test;Y-balance test;Flow-Mediated Dilation;Carotid Intima-Media Thickness;Carotid Ultrasound;Hemodynamics;Body Composition;Muscle Ultrasound;Pulmonary Function Indices;Vital Capacity ;Mechanisms Associated with Skeletal Aging;Respiratory-Related Indices;Cortisol;Immunomodulatory Bioactive Substances;Melatonin;Actigraphy-Related Metrics;Adenosine;?-aminobutyric acid; | — |
Countries
China
Contacts
Public ContactShaojun Lyu
Beijing Normal University
Outcome results
None listed