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The effect of Taohong Siwu Decoction on the healing of hip fracture in the elderly by regulating VEGF / PI3K / Akt signaling pathway

The effect of Taohong Siwu Decoction on the healing of hip fracture in the elderly by regulating VEGF / PI3K / Akt signaling pathway

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026000630
Enrollment
Unknown
Registered
2026-03-19
Start date
2025-05-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hip fracture in the elderly

Interventions

observer group:Add Taohong Siwu Decoction based on the control group

Sponsors

The Second Peoples Hospital of Hunan Province (Brain Hospital of Hunan Provincial)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 95 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: (1) Meeting the diagnostic criteria for hip fractures in the elderly in both Western medicine and Traditional Chinese Medicine and confirmed by relevant imaging examinations; (2) Unilateral fracture; (3) Having indications for reduction and internal fixation surgery; (4) Good compliance with treatment.

Exclusion criteria

Exclusion criteria: Exclusion criteria: (1) Those with a history of hip trauma; (2) Those who have undergone joint replacement surgery; (3) Those with old hip fractures; (4) Those with severe organ dysfunction; (5) Those with endocrine system diseases; (6) Those with coagulation disorders.

Design outcomes

Primary

MeasureTime frame
Vascular Endothelial Growth Factor(VEGF);Phosphoinositide 3-Kinase(PI3K);Protein Kinase B(AKT);Bone alkaline phosphatase(BALP);Procollagen Type I N-terminal Propeptide(PINP);Tartrate-resistant Acid Phosphatase 5b(TRACP-5b);Cross-linked C-telopeptide of Type I Collagen(CTX-I);Vascular Endothelial Growth Factor(VEGF);

Countries

china

Contacts

Public ContactLei Mi

The Second Peoples Hospital of Hunan Province (Brain Hospital of Hunan Provincial)

2005291@hnucm.edu.cn13975890917

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Apr 4, 2026