Diarrhea-predominant Irritable Bowel Syndrome
Conditions
Sponsors
Fujian University of Traditional Chinese Medicine Affiliated Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients meeting the diagnostic criteria for IBS-D: Diagnosis criteria refer to the "2020 Chinese Expert Consensus on Irritable Bowel Syndrome" and the "Functional Gastrointestinal Disorders: Rome IV" published by the Rome Foundation in 2016. Symptoms must have been present for at least 6 months prior to diagnosis, with the last 3 months meeting the following diagnostic criteria: (1) Recurrent abdominal pain, bloating, or abdominal discomfort in the past 3 months, occurring at least 1 day per week, accompanied by 2 or more of the following: 1) Related to defecation; 2) Accompanied by changes in bowel frequency; 3) Accompanied by changes in stool consistency (appearance). (2) Exclusion of other organic diseases; (3) Diagnostic criteria for IBS-D subtypes require stool consistency to meet specific standards: more than 1/4 of stools during abnormal bowel movements are of type 6 or 7 on the Bristol Stool Form Scale (mucous or watery stools), and less than 1/4 of stools are of type 1 or 2 (hard or lumpy stools). (4) The Bristol Stool Form Scale categorizes stool shapes into 7 types based on shape and continuity: 1: Pellet-like stools, difficult to pass; 2: Sausage-shaped with cracks on the surface; 3: Sausage-shaped with cracks; 4: Sausage-shaped; 5: Soft, lumpy stools; 6: Fluffy, mushy stools; 7: Watery stools. 2. Patients aged between 18-75 years, with no gender restrictions; 3. Patients sign the "Informed Consent Form" and voluntarily agree to participate in this clinical study.
Exclusion criteria
Exclusion criteria: 1. Non-diarrheal IBS; 2. Endoscopic examination reveals organic diseases in the gastrointestinal tract or systemic diseases affecting gastrointestinal motility (e.g., hyperthyroidism, diabetes, etc.); 3. Long-term use of medications that may interfere with gastrointestinal function (including probiotics, laxatives, antidiarrheals, 5-HT3 receptor antagonists, calcium channel blockers, anticholinergics, and antidepressant/anxiolytic drugs, etc.); 4. Severe diseases of major organs (e.g., heart, liver, kidney), hematological disorders, or malignant tumors; 5. History of abdominal surgery (e.g., gallbladder removal, etc.); 6. Pregnant or breastfeeding women; 7. Patients with neurological or psychiatric disorders. (Note: Meeting any of the above criteria results in exclusion.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms related to diarrhea-predominant irritable bowel syndrome in the patient.;Patient with clinical symptoms associated with diarrhea-predominant irritable bowel syndrome (IBS) - upper abdominal pain location.;Patient clinical symptoms associated with diarrhea-predominant irritable bowel syndrome (IBS) - epigastric pain characteristics.;Patient's clinical symptoms related to diarrhea-predominant irritable bowel syndrome (IBS) - aggravating factors of epigastric pain.;Patient with diarrhea-predominant irritable bowel syndrome (IBS-D) related clinical symptoms - upper abdominal pain relief factors.;The patient has clinical symptoms related to diarrhea-predominant irritable bowel syndrome (IBS-D), specifically epigastric pain in relation to defecation.;The patient has clinical symptoms related to diarrhea-predominant irritable bowel syndrome (IBS-D), including epigastric pain and associated symptoms.;Patient with diarrhea-predominant irritable bowel syndrome and clinical symptoms of abdominal distension.;Clinical symptoms related to diarrhea-predominant irritable bowel syndrome in the patient - gastric gurgling and discomfort.;The patient has clinical symptoms associated with diarrhea-predominant irritable bowel syndrome (IBS), including thirst and drinking.;The patient has clinical symptoms related to diarrhea-predominant irritable bowel syndrome - appetite.;Patient with diarrhea-predominant irritable bowel syndrome (IBS-D) associated clinical symptoms - food preferences.;Patient with Irritable Bowel Syndrome with Diarrhea (IBS-D) related clinical symptoms - taste;The patient presents with clinical symptoms related to diarrhea-predominant irritable bowel syndrome (IBS-D), including belching with sour taste.;The patient has clinical symptoms related to diarrhea-predominant irritable bowel syndrome - hiccups.;Patient clinical symptoms associated with diarrhea-predominant irritable bowel syndrome (IBS) - stool condition.;General condition of the patient - To | — |
Secondary
| Measure | Time frame |
|---|---|
| General condition of the patient - fever and chills;General condition of the patient: fatigue and weakness.;General condition of the patient - Urination status;The patient's general physical condition and emotional state.;Patient's overall general condition - Sleep; | — |
Countries
China
Contacts
Public ContactZhi Lin
Fujian University of Traditional Chinese Medicine Affiliated Second People's Hospital
Outcome results
None listed