The diminished ovarian reserve in advanced age.
Conditions
Interventions
Young control group:GnRH-ant protocol for controlled ovarian stimulation
administration of r-FSH (Gonal-f, Merck Serono) begins on day 2-3 of the menstrual cycle to stimulate follicular growth. During the ovulation induction process, the dosage of r-FSH is adjusted based o
Elderly control group:GnRH-ant protocol for controlled ovarian stimulation
Elderly Chinese medicine group:GnRH ant protocol controlled ovarian stimulation
. When at least three dominant follicles were = 18mm, GnRH-a and r-FSH were stopped, 10000 IU of human chorionic gonadotropin (hCG) was injected intramuscularly to trigger oocyte maturation, and the e
Sponsors
Shandong University of Traditional Chinese Medicine Affiliated Hospital
Eligibility
Sex/Gender
Female
Age
21 Years to 42 Years
Inclusion criteria
Inclusion criteria: Young control group: 1. Patients with infertility undergoing IVF-ET; 2. Age between 21 and 35 years old; 3. AMH = 1.2 ng/mL; 4. Signed informed consent, voluntarily participating in this study and actively cooperating. Older control group and older medication group: 1. Patients with infertility undergoing IVF-ET; 2. Age between 35 and 42 years old; 3. AFC < 5 and AMH < 1.2 ng/mL; 4. Signed informed consent, voluntarily participating in this study and actively cooperating.
Exclusion criteria
Exclusion criteria: 1. BMI = 28 kg/m²; 2. Chromosomal abnormalities in both partners' karyotypes, infertility caused by genetic factors; 3. Suffering from polycystic ovary syndrome, endometriosis, hyperprolactinemia, uterine fibroids, or other gynecological diseases; congenital or acquired uterine developmental abnormalities, and other contraindications for assisted reproductive technology; 4. Use of any steroid hormone medications in the past 3 months prior to enrollment; 5. Severe systemic diseases (physical or mental) in the female partner that make pregnancy unbearable; history of radiotherapy or chemotherapy; 6. Currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Retrieved Oocytes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gonadotropin administration time;Total gonadotropin dose;Average dosage of gonadotropin;Serum estradiol on trigger day;Serum progesterone on trigger day;Normal fertilization number;Number of transferable embryos;Number of high-quality embryos;Mature Oocyte Rate / MII Oocyte Rate;Cancellation cycle rate;Positive pregnancy;Implantation rate;Clinical pregnancy; | — |
Countries
China
Contacts
Public ContactGuo Ying
Shandong University of Traditional Chinese Medicine Affiliated Hospital
Outcome results
None listed