Acute Exacerbation of Chronic Obstructive Pulmonary Disease (Phlegm-Heat Blocking the Lungs Syndrome)
Conditions
Interventions
Sponsors
Kashgar City People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age between 40 and 80 years (inclusive) at the time of enrollment, regardless of gender; good verbal communication skills. (2) Weight between 45 kg and 85 kg (inclusive). (3) Diagnosed with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) according to the GOLD guidelines and requiring hospitalization, with an acute exacerbation duration of =7 days, and belonging to acute exacerbation grade I or II patients. (4) Patients with TCM syndrome differentiation as phlegm-heat blocking the lungs; patients with Mongolian medicine syndrome differentiation as hiira type. (5) The subject has given informed consent and has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with heart failure asthma, bronchial asthma, bronchiectasis, active pulmonary tuberculosis, pulmonary interstitial fibrosis, pneumothorax, pleural effusion, pulmonary embolism, neuromuscular diseases affecting respiratory function; severe acute exacerbation of COPD requiring ICU admission. (2) Patients with TCM syndrome differentiation belonging to cold syndrome; (3) Patients with malignant tumors; (4) Patients with hematological diseases such as leukemia, aplastic anemia, myelodysplastic syndromes, thrombocytopenia, multiple myeloma; (5) Pregnant women or those planning to become pregnant, lactating women; (6) Patients with severe damage to heart, liver, and kidney function: cardiac function class 3-4, ALT and/or AST more than twice the upper limit of normal, glomerular filtration rate <60%; (7) Patients with rheumatic immune diseases who need to use glucocorticoids and immunosuppressants; (8) Patients who have received systemic glucocorticoid treatment within 2 weeks or participated in other drug clinical trials within 3 months; (9) Other situations deemed unsuitable for inclusion by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sputum Composite Index Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Chinese-Mongolian Medicine Syndrome Quantification Scoring;CAT (Chronic Obstructive Pulmonary Disease Assessment Test);Inflammatory Cytokine Testing;Modified Medical Research Council Dyspnea Scale;Sputum and serum inflammatory cytokines (IL-6, IL-8, IL-10); | — |
Countries
China
Contacts
Public ContactMai Mai Ti Tu Sun · Yalikun
Kashi City People's Hospital
Outcome results
None listed