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Machine Learning and MRI-Based Prediction of Efficacy and Mechanisms of acupuncture at the Knee Combined with PRP Injection for Early-to-Middle-Stage Knee Osteoarthritis

Machine Learning and MRI-Based Prediction of Efficacy and Mechanisms of acupuncture at the Knee Combined with PRP Injection for Early-to-Middle-Stage Knee Osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2026000586
Enrollment
Unknown
Registered
2026-03-18
Start date
2026-04-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

3-Needle Therapy Group at the Knee:3-Needle Therapy at the Knee
Standard Treatment Group:Topical Ketoprofen Gel Patch

Sponsors

Shaanxi Traditional Chinese Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients who meet the diagnostic criteria of both traditional Chinese and Western medicine and are classified as having early-to-middle-stage disease severity.2.Patients aged between 30 and 80 years (inclusive), regardless of gender.3.Patients enrolled based on the unilateral knee; for those with bilateral involvement, the more severely affected side is selected.4.No use of medications related to knee osteoarthritis treatment within the past week.5.Patients who are conscious, without severe visual impairment or hearing impairment, and with normal cognitive and comprehension functions.6.Patients who voluntarily accept the content of this study and agree to sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.After enrollment, patients found not to meet the inclusion criteria.2.Patients under 30 years of age or over 80 years of age.3.Women who are currently pregnant or planning to become pregnant.4.Patients with mental disorders or intellectual disabilities.5.Patients with severe cardiac, cerebrovascular, hepatic, renal diseases, or other severe metabolic disorders, as well as bone tumors.6.Patients allergic to ketoprofen, aspirin, or other nonsteroidal anti-inflammatory drugs (NSAIDs); those with a history of "aspirin-induced asthma."7.Patients concurrently participating in other studies.Note: Patients meeting any of the above criteria should be excluded.

Design outcomes

Primary

MeasureTime frame
Western Ontario and McMaster Universities Osteoarthritis Index;—

Secondary

MeasureTime frame
Visual Analogue Scale;Japanese Orthopaedic Association Scores for Knee Osteoarthritis;Interleukin-1ß;Interleukin-6;Tumor Necrosis Factor-a;C-Reactive Protein;—

Countries

China

Contacts

Public ContactQin weixun

Shaanxi Traditional Chinese Medicine Hospital

qinweixun@foxmail.com13389228681

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Apr 4, 2026