aging
Conditions
Interventions
Traditional Chinese Medicine Group:Chinese herbal medicine, transcutaneous electrical nerve stimulation (TENS), ear acupoint application, Tai Chi, for three months.
Sports Group:Exercise guidance for 3 months
Sponsors
Nanjing Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Age between 50 and 80 years old; 2) Physically healthy with the ability to live independently; 3) Without a history of major illnesses; 4) Montreal Cognitive Assessment (MOCA) score: MoCA >22 points (for participants with less than 9 years or 6 years of education, or those older than 70 years, the score can be reduced by 1-2 points accordingly); 5) If participants are currently taking medication, they must maintain a stable dose for at least 1 month prior to participation and should not expect any changes in their medication regimen; 6) Sign the informed consent form, voluntarily participate in this study, and be able to cooperate in completing the corresponding assessments and follow-ups.
Exclusion criteria
Exclusion criteria: 1) Existence of motor system activity or limb disability 2) Severe illness or acute onset of infection within 1 month prior to the start of the trial 3) Severe primary liver, lung, kidney, or hematological system diseases; life-threatening conditions such as tumors or AIDS; history of heart disease with clinical significance or abnormal ECG; white blood cell count <3.0×10^9/L; or autoimmune-related diseases 4) Individuals with cardiac pacemakers or electronic/mechanical implants 5) History of chronic diseases with unstable or poorly controlled conditions, such as unstable angina, recent myocardial infarction (within 6 months), or uncontrolled hypertension 6) Major surgery within the past 1 month, or planned surgery within the next 3 months 7) Severe mental health disorders, such as major depressive disorder or bipolar affective disorder 8) Legally defined individuals with disabilities (blindness, deafness, mutism, intellectual disabilities, mental disorders, etc.) 9) History of suspected or confirmed alcohol or substance abuse 10) Frequent changes in work or living environment that may lead to loss to follow-up 11) Allergic constitution with a history of allergies to two or more medications or foods; allergy to components of the study drug 12) Pregnant women, breastfeeding women, or individuals unable to participate due to physical condition 13) Individuals currently participating in other clinical trials 14) Individuals deemed unsuitable for participation in this study by the investigator after assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal oxygen consumption;Six-minute-walk test;400-meters-walk test;Muslce mass;Montreal Cognitive Assessment and The Mini Mental State Examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| The ratio of CD4/CD8 cell subsets in immune cells;Inflammation-related cytokine levels;Cambridge Neuropsychological Test Automatic Battery;Comprehensive Geriatric Assessment;One-Repetition Maximum ;Muscle mass under CT scanning;Balance test;Foot pressure distribution;Dynamic balance test;Influenza vaccine antibody titer;Lymphocyte/Neutrophil ratio;Inflammatory cytokine test;Pittsburgh Sleep Quality Index (PSQI); | — |
Countries
China
Contacts
Public ContactLuo Tian Jiong
Nanjing Hospital of Chinese Medicine
Outcome results
None listed