Obstetric antiphospholipid syndrome
Conditions
Interventions
treatment group:Oral Anzi Tiaochong Tang combined with aspirin
control group:Oral aspirin
Sponsors
Shenzhen Maternity and Child Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Those who meet the diagnostic criteria of Western and Traditional Chinese Medicine, aged 18-40, voluntarily participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: Those who do not meet the diagnostic criteria, have incomplete data, and affect the assessment of therapeutic efficacy; Both spouses have one or more chromosomal abnormalities; The male's semen routine is severely abnormal; Women with endocrine related diseases affecting pregnancy such as diabetes, hyperthyroidism, hypothyroidism, hyperprolactinemia, Addison syndrome, Cushing syndrome, etc. were excluded; Exclude patients with severe organ failure and cachexia who cannot tolerate normal pregnancy; Excluding immune related factors other than APS that may affect pregnancy; For example: immunodeficiency, autoimmune diseases (differentiated and undifferentiated connective tissue diseases, etc.); Exclude anatomical factors of the reproductive tract that may affect pregnancy, such as severe uterine malformations, intrauterine adhesions, uterine fibroids, endometriosis, etc; Exclude patients with hereditary or acquired thrombophilia syndrome; Individuals with a history of polycystic ovary syndrome and premature ovarian failure; The woman has a long history of heavy smoking and alcohol abuse. Pregnant or lactating patients; Patients may have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD19+CD24hiCD27+regulatory B cells;CD3+CD4+T lymphocytes;CD16+CD56+natural killer (NK) cells;lupus anticoagulant(LA);Anticardiolipin antibody (ACA);ß 2 glycoprotein antibody titer(anti-ß2-GPI);D-dimer(D-D);Plasma prothrombin time(PT);Activated partial thromboplastin time(APTT);fibrinogen(FIB);CD3+CD8+T lymphocytes; | — |
Countries
China
Contacts
Public ContactChen Yan
Shenzhen Maternity and Child Healthcare Hospital
Outcome results
None listed