Brucellosis
Conditions
Interventions
Fire Cupping Group:Fire cupping therapy + conventional antibacterial therapy (doxycycline combined with rifampicin)
Paracetamol Group:Oral paracetamol + conventional antibacterial therapy (doxycycline combined with rifampicin)
Usual Care Group:conventional antibacterial therapy (doxycycline combined with rifampicin)
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age and Diagnosis: Aged 18-80 years, diagnosed with brucellosis (with a clear history of contact with infected animals and meeting any one of the following laboratory criteria: serum agglutination test titer SAT =1:160; isolation of Brucella from blood or bone marrow culture; positive for Brucella-specific IgM antibodies). 2. Pain Condition: Presence of clear low back pain or joint pain symptoms, with a pain duration of =3 days, and a pain Numerical Rating Scale (NRS) score of =4 points during activity. 3. Treatment Indication: Meeting the indication for antibacterial therapy for brucellosis (typically the doxycycline combined with rifampicin regimen). 4. Informed Consent and Compliance: Voluntarily agree to participate in this study and provide written informed consent; able to understand the study requirements and cooperate to complete all treatments and follow-up assessments.
Exclusion criteria
Exclusion criteria: 1. Pain from Specific Causes: Low back pain caused by specific organic or pathological reasons such as disc herniation, spinal stenosis, fracture, spinal tumor, or axial spondyloarthritis. 2. Contraindications to Cupping: Presence of contraindications to cupping therapy, such as coagulation disorders, use of anticoagulant medications, skin infection, ulceration, or severe skin disease at the treatment site. 3. Severe Hepatic or Renal Insufficiency: Severe hepatic or renal dysfunction (alanine aminotransferase ALT or aspartate aminotransferase AST > 3 times the upper limit of normal, or serum creatinine > 133 µmol/L). 4. Specific Physiological Status: Pregnant or lactating women. 5. Post-operative Patients: Patients within 1 month after surgery. 6. Recent Intervention History: Having received cupping therapy, physical therapy, or other analgesic interventions within the past 4 weeks. 7. Concurrent Severe Diseases: Concurrent other active infectious diseases (e.g., tuberculosis, typhoid fever) or malignant tumors (e.g., lymphoma). 8. Inability to Cooperate with Assessment: Presence of mental disorders, cognitive impairment, or other reasons that prevent cooperation with study assessments. 9. Other Poorly Controlled Severe Diseases: Severe hypertension and diabetes that are not effectively controlled.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity on movement (NRS score) After the intervention ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain intensity at rest (NRS score);Pain intensity on movement (NRS score) ;Functional Status; | — |
Countries
China
Contacts
Public ContactHaitao Jia
Lanzhou University Second Hospital
Outcome results
None listed