Post-Stroke Cognitive Impairment
Conditions
Interventions
Exposure group:Acupuncture Treatment+Conventional Western Medicine
Non-exposure group:Conventional Western Medicine
Sponsors
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1)Meeting the diagnostic criteria for ischemic stroke, with first onset, stroke course < 180 days, aged = 18 years, and no restriction on the modified Rankin Scale (mRS) score. 2)Meeting the diagnostic criteria for post-ischemic stroke cognitive impairment: presence of impairment in one or more cognitive domains, without meeting the diagnostic criteria for dementia; score on the Montreal Cognitive Assessment (MoCA) ranging from 21 to 25 (Note: the original "20 points < MoCA < 26 points" is converted to an integer score range consistent with clinical practice, as MoCA scores are integers). 3)Being able to understand and cooperate with basic cognitive function assessments. 4)Having at least one caregiver or family member available to assist with follow-up visits.
Exclusion criteria
Exclusion criteria: 1) NIHSS score = 21; 2) Unable to cooperate with cognitive assessment due to visual impairment or aphasia; 3) Having symptoms of cognitive domain impairment or diagnosed with cognitive impairment/dementia prior to stroke; or complicated with neoplastic diseases, infectious diseases, Alzheimer's disease (AD) or other neurodegenerative diseases; 4) Previous use of cognitive-improving drugs such as cholinesterase inhibitors and citicoline sodium, or received cognitive-improving acupuncture treatment; 5) Unable to cooperate with the completion of this study due to mental illness, severe cognitive or emotional disorders; 6) Having severe life-threatening diseases involving the cardiovascular, respiratory, digestive, urinary or other systems; 7) No long-term cohabitants or caregivers; 8) Pregnant, planning pregnancy, or lactating women; 9) Having internal metallic implants such as steel plates and thus unable to undergo magnetic resonance (MR) examination; 10) Participated in clinical trials related to acupuncture or cognitive impairment within the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| National Institute of Health Stroke Scale;Traditional Chinese Medicine Information ;Electroencephalogram (EEG) Data ;MRI data;Serum IL-1ß, IL-6.;Modified Bathel Index; | — |
Countries
China
Contacts
Public ContactLi Guiping
The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
Outcome results
None listed