Hand-Foot Syndrome in Abdominopelvic Tumor Patients After Targeted Therapy
Conditions
Interventions
Control Group:Single-targeted therapy
Treatment group:Targeted therapy plus cheek acupuncture therapy group
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-75 years old; 2) Abdominal and pelvic malignant tumors with indications for targeted therapy; 3) Expected survival >12 months; 4) ECOG performance status 0-1; 5) Child-Pugh liver function score 5-7 points; 6) Blood, liver, and kidney function meet the following criteria: a) Neutrophil count =1.5×10^9/L b) Platelet count =75×10^9/L c) Hemoglobin concentration =90g/L d) Serum albumin concentration =30g/L e) Total bilirubin =50umol/L f) AST, ALT <5 times the upper limit of normal, ALP <4 times the upper limit of normal g) International normalized ratio =2.3 h) Creatinine <1.5 times the upper limit of normal 7) Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1) Concurrent with other malignant tumors or having other malignant tumors within 5 years prior to enrollment; 2) Facial skin surface ulceration or infection; 3) History of local hand-foot skin diseases, such as tinea pedis or hyperkeratosis, prior to treatment; 4) Subjects currently receiving other treatments that may cause skin toxicity; 5) Subjects currently receiving other medications for hand-foot syndrome, such as COX-2 enzyme inhibitors; 6) Refusal to undergo cheek acupuncture treatment; 7) Severe heart, kidney, or other organ dysfunction, such as arrhythmia (requiring anti-arrhythmic medications or pacemaker implantation), uncontrolled hypertension, history of myocardial infarction within 6 months, QT interval prolongation >450 ms, or congestive heart failure >NYHA class 2; 8) Pregnant, breastfeeding women, or subjects planning pregnancy within the next two years; 9) Other severe conditions, such as alcoholism, drug abuse, or mental/psychiatric disorders, which may affect informed consent or compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hand-Foot Syndrome Grading Evaluation;Skin Health Score;Quality of Life Rating;Fatigue Rating; | — |
Countries
China
Contacts
Public ContactZhang Shijun
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed