knee osteoarthritis
Conditions
Interventions
control group:Diclofenac Capsules
Sponsors
The Third People's Hospital affiliated to Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meets the diagnostic criteria of KOA; (2) Meets the diagnostic and syndrome differentiation criteria of traditional Chinese medicine; (3) Radiological X-ray K-L classification: grades I-III, accompanied by narrowed joint space, cystic changes or sclerosis of subchondral bone; (4) Age 50-75 years old, gender not limited; (5) Has not taken or injected drugs affecting bone metabolism in the past 3 months; (6) The patient is willing to participate in and cooperate with this study, and signs the informed consent form for clinical research.
Exclusion criteria
Exclusion criteria: (1) Patients with secondary KOA due to knee joint trauma; (2) Patients with combined dysfunction of important organs such as heart, liver and kidney; (3) Patients with malignant tumors or local benign tumors in the knee joint; (4) Patients with rheumatoid arthritis, ankylosing spondylitis, gout, metabolic bone diseases and other serious diseases; (5) Patients with history of knee joint surgery; (6) Patients with cognitive impairment and mental disorders; (7) Women in lactation or pregnancy; (8) Patients unsuitable for MRI examination; (9) Patients allergic to the drugs or drug components in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ?T2 relaxation time;Whole Organ Magnetic Resonance Imaging Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The Western Ontario and McMaster Universities Osteoarthritis Index;Visual Analogue Scale?;Aggrecan;Osteoprotegerin;Receptor Activator of Nuclear Factor-? B Ligand; | — |
Countries
China
Contacts
Public ContactChen Peng
The Third People's Hospital affiliated to Fujian University of Traditional Chinese Medicine
Outcome results
None listed