Gastric cancer-related sarcopenia
Conditions
Interventions
Trial group:Electroacupuncture intervention with basic chemotherapy
Control group:Sham electroacupuncture intervention with basic chemotherapy
Sponsors
Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated with Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Pathologically diagnosed gastric cancer with a history of gastrectomy, concurrently meeting the diagnostic criteria for sarcopenia; TNM stage II-III; and presenting with the traditional Chinese medicine syndrome pattern of Qi and Blood Deficiency. (2) Scheduled to receive at least 2 cycles of platinum-based chemotherapy in combination with fluoropyrimidine agents, based on the pathological results and individual patient status. (3) Aged between 45 and 80 years (inclusive), regardless of gender. (4) Karnofsky Performance Status (KPS) score = 60, with an estimated life expectancy exceeding 3 months. (5) Mentally clear and cognitively intact, capable of understanding assessment scales and completing questionnaires independently. (6) Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Presence of other concurrent malignancies or significant primary diseases affecting the cardiovascular, cerebrovascular, hepatic, renal, endocrine, hematological, or neuropsychiatric systems, or a history of bleeding tendency. (2) Diagnosis of major infectious diseases such as AIDS, Hepatitis B, Hepatitis C, or Syphilis. (3) Receipt of Traditional Chinese Medicine, acupuncture, or other related therapies within 4 weeks prior to enrollment, or participation in other drug clinical trials during the same period; or any history of acupuncture treatment within the past 5 years. (4) Known allergy to acupuncture or severe psychological aversion/fear that would preclude cooperation with the treatment. (5) Chronic alcohol or tobacco dependence. (6) Women who are pregnant or lactating. Patients meeting any of the above criteria will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Appendicular skeletal muscle mass index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Grip strength;6 meters daily walking speed;Symptom and signs score of Chinese Medicine;EORTC QLQ-C30 (V3.0) Chinese Version.;Nutritional and Hematological Indices (Albumin, Hemoglobin);Inflammatory markers (IL-6, TNF-a, CRP); | — |
Countries
China
Contacts
Public ContactLi Jing
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed