Obesity
Conditions
Interventions
Acupoint Implantation Group:Acupuncture point embedding therapy (using disposable embedding needles and 2/0 protein sutures, performing embedding operations at bilateral Zhongwan (CV12), Xiaowan (CV10
Sham group:Sham acupuncture thread embedding therapy (using single-use thread embedding needles without inserting protein thread, performing superficial needling operations in non-acupoint areas 1 cun
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Meets diagnostic criteria for obesity; (2) Aged 18 to 60 years, gender unrestricted; (3) No prior weight loss treatments within the past three months prior to entering the study; (4) No participation in other weight loss-related clinical studies or activity programs in the past three months; (5) Self-reported weight changes within 5% in the past six months prior to screening, regardless of medical records; (6) Informed consent obtained prior to any trial-related activities.
Exclusion criteria
Exclusion criteria: (1) Known secondary obesity due to endocrine causes (e.g., untreated hypothyroidism, Cushing's syndrome, diagnosed polycystic ovary syndrome); (2) Receipt of medications that may cause significant weight gain within three months prior to entering the study, including systemic corticosteroids (except short-term treatment, i.e., 7-10 days), antidepressants, antipsychotics, mood stabilizers, antiepileptics, and hormonal contraceptives; (3) Presence of cerebrocardiovascular diseases that may affect brain function imaging indicators, including but not limited to chronic kidney failure or liver failure, congestive heart failure, myocardial infarction, and patients with brain parenchymal damage; (4) Presence of other physiological or pathological conditions that may affect the observation or judgment of efficacy indicators, such as malignant tumors, cirrhosis, and other severe primary diseases, as well as mental disorders; (5) Exclusion of infectious diseases, including viral infections, bacterial infections, parasitic infections, and other diseases withinfection foci or systemic infections; (6) Exclusion of women in pregnancy, peripartum period, lactation period, or planning to become pregnant during the study, as well as patients in the perioperative period; (7) Exclusion of patients with metal implants or other reasons that prevent MRI examinations; (8) Exclusion of patients with a tendency to develop scars or allergic constitutions; (9) Any other obstacles, unwillingness, or inability, in the investigator's opinion, that may jeopardize the safety of the participants or compliance with the protocol, which are not covered by the aforementioned exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Mass Index;Functional Connectivity (FC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Weight;waist;Appetite Visual Analogue Scale (VAS);Three-Factor Eating Questionnaire(TFEQ);Control of Eating Questionnaire (CoEQ);Fractional Amplitude of Low-Frequency Fluctuations (fALFF);Regional Homogeneity (ReHo);Leptin;insulin;Ghrelin; | — |
Countries
China
Contacts
Public ContactQianwen Xie, Changcai Xie
Guangdong Provincial Hospital of Chinese Medicine Zhuhai Branch, Guangdong Provincial Hospital of Chinese Medicine (Zhuhai Acupuncture Department)
Outcome results
None listed