Hypertension associated with Mild Cognitive Impairment
Conditions
Interventions
taVNS Group:Select the left conchal cavity and the area within the conchal boat where the auricular branches of the vagus nerve are densely distributed. The auricular points correspond to the heart (C
sham taVNS Group:Select the distribution area of the non-vagus nerve auricular branch on the left auricular vessel, with the auricular points corresponding to the elbow (SF3) and shoulder (SF4.5). The
Sponsors
Chengdu Integrated Traditional Chinese Medicine & Western Medicine Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) It meets the diagnostic criteria of HT and MCI and there is a clear sequential relationship between HT and cognitive impairment with relatively stable blood pressure control; (2) Cognitive decline for more than 3 months and symptoms are relatively stable: Montreal Cognitive Assessment Scale (MOCA) score =18 points and < 26 points; The Clinical Dementia Scale (CDR) score < 1 point. The Activities of Daily Living (ADL) score< 22 points and no more than one item in the individual score =3 points. (3) Age 45 to 75 right-handed; (4) Education level: Primary school (6 years or more) capable of correctly understanding and completing the scales; (5) Patients or their family members who sign the informed consent form and cooperate with the treatment. Note: Only patients who meet all the above criteria simultaneously can be included in this study.
Exclusion criteria
Exclusion criteria: (1) Currently undergoing other treatments that may interfere with cognitive function such as taking medications that affect cognition (donepezil memantine rivaroxamine etc.); (2) Neurological diseases or chronic diseases systemic diseases that have been diagnosed as potentially affecting cognitive function; (3) Imaging findings include multiple infarctions infarctions in important memory regions of the brain or severe white matter lesions (Fazekas score >3) etc. (4) There are secondary hypertension refractory hypertension or clinical complications and target organ damage; (5) Those who have aphasia hearing impairment or muscle strength less than grade 3 and other functional impairments and are unable to cooperate with the test; (6) Patients with diabetes or those with a body mass index (BMI) 35 scores); (8) Those with bleeding disorders or skin diseases; (9) Drug addicts smokers and heavy drinkers; (10) Women who are menstruating pregnant planning to become pregnant or breastfeeding; (11) Has received any acupuncture treatment within 3 months or participated in other clinical studies. (12) Those with other contraindications to brain functions. Note: Any patient who meets any of the above conditions will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination(MMSE);verbal fluency test, VFT;the shape trail test, STT;Auditory Verbal Learning Test;Blood pressure;Dynamic electrocardiogram;Electroencephalogram; | — |
Countries
China
Contacts
Public ContactXiao Luo
Chengdu Integrated Traditional Chinese Medicine & Western Medicine Hospital
Outcome results
None listed