Cervical Spondylotic Radiculopathy(CSR)
Conditions
Interventions
Control Group:nan
Sponsors
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Experimental Group: 1) Meets the diagnostic criteria for cervical radiculopathy; 2) Right-handed (to ensure consistency of the dominant cerebral hemisphere within the experimental group); 3) Aged 30-75 years, regardless of gender; 4) Pain persisting for more than 6 months; 5) Neck pain intensity =30 mm on a 100-mm Visual Analogue Scale (VAS) in the preceding week; 6) No metal implants in the body and no contraindications for MRI examination; 7) Agrees to participate in the study and signs the informed consent form. (2) Control Group: 1) Right-handed (to ensure consistency of the dominant cerebral hemisphere within the control group); 2) Aged 30-75 years, regardless of gender; 3) Confirmed to be in good health through physical examination, with no organic or significant functional diseases; 4) No family history of any psychiatric or neurological hereditary diseases; 5) Has not participated in any research similar to this trial; 6) No physical abnormalities during the trial phase (e.g., cold, headache, cough, etc.); 7) Has not taken any stimulant drugs within the last 2 months; 8) No metal implants in the body and no contraindications for functional magnetic resonance imaging; 9) Agrees to participate in the study and signs the informed consent form.
Exclusion criteria
Exclusion criteria: Experimental group 1) Neck pain caused by spinal cord injury, cervical spine fracture, congenital spinal deformity, spinal stenosis, or tumors (excluded by physicians based on clinical symptoms, signs, and imaging examinations). 2) Complicated with other pain conditions, including inflammatory rheumatic diseases, neoplastic diseases, metabolic diseases, neurological diseases, fibromyalgia syndrome, etc. 3) Complicated with severe primary diseases of the cardiovascular, hypertension, digestive, hematopoietic systems, liver, kidneys, etc. 4) Severe hearing or visual impairment. 5) Inability to cooperate with examinations or contraindications for MRI such as claustrophobia. 6) Severe cranial anatomical asymmetry or definite lesions found on MRI scanning. 7) Pregnant, lactating, or menstruating women. 8) Previous cervical spine surgery or history of invasive spinal treatment. 9) Severe mental illness and physical comorbidities (e.g., HAMD score > 17). 10) Currently receiving any treatment for neck pain or have received relevant treatment (e.g., painkillers) within the past three months. Note: Exclusion criteria apply if any of the above conditions are met. Control group 1) Menstruating, pregnant, or lactating women. 2) Subjects with contraindications for MRI such as claustrophobia. 3) Severe cranial anatomical asymmetry or definite lesions found on MRI scanning. 4) Diseases related to neurological dysfunction. 5) Inability to cooperate and complete this project. Note: Exclusion criteria apply if any of the above conditions are met.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in multimodal magnetic resonance brain networks from baseline after 4 weeks of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale for Pain (VAS Pain) score;Neck Disability Index (NDI) score;12-Item Short Form Health Survey (SF-12) score;Hamilton Depression Rating Scale (HAMD) score; | — |
Countries
China
Contacts
Public ContactHua ZHANG
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Outcome results
None listed