Chemotherapy Related Cognitive Impairment
Conditions
Interventions
Experimental Group:Ginkgo biloba extract tablets, three times daily, one tablet each time, orally, plus chemotherapy/follow-up.
Control Group:Ginkgo Ketone Ester Placebo, 3 times daily, 1 tablet each time, oral administration + chemotherapy/follow-up
Sponsors
Shanghai University of Traditional Chinese Medicine Affiliated Longhua Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1)Pathological examination confirmed the diagnosis of breast cancer, with pathological staging at I~III; 2) Postoperative patients who initially received anthracycline-containing chemotherapy according to standard protocols and dosages, without recurrence, metastasis, or intracranial abnormalities; 3) Normal general cognitive function, basically normal activities of daily living, no functional impairments in hearing, vision, or language, and a Karnofsky score =60; 4) Female patients aged 18-65 years (including 18 and 65 years); 5) Willing to undergo treatment, observation, and all required examinations.
Exclusion criteria
Exclusion criteria: 1. Patients with severe anxiety, depression, and schizophrenia; 2. Patients with an estimated life expectancy of less than 6 months; 3. Patients with severe primary diseases of the cardiovascular, liver, kidney, or hematopoietic systems; 4. Nursing mothers, pregnant women, or those planning to become pregnant; 5. Individuals with a history of alcohol or substance dependence, or those taking medications that improve cerebral circulation, brain metabolism, or neuroprotective agents that may affect cognitive function; 6. Individuals with an allergic constitution who are allergic to Ginkgo biloba extract.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chemotherapy-Induced Cognitive Impairment Incidence Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Memory Assessment;Attention Function Assessment;Executive Function Assessment;Anxiety ;Depression;Sleep quality;Functional Assessment - Cognitive Function;Traditional Chinese Medicine Symptom Evaluation;Subjective Cognitive Evaluation; | — |
Countries
China
Contacts
Public ContactSun Chenping
Shanghai University of Traditional Chinese Medicine Affiliated Longhua Hospital
Outcome results
None listed