Parkinson's disease
Conditions
Interventions
A:(Weeks 1-4), 20Hz transcutaneous auricular vagus nerve stimulation (taVNS) combined with conventional drug treatment was administered. (Weeks 5-8), taVNS intervention was stopped and only convention
B:(Weeks 1-4), 4Hz transcutaneous auricular vagus nerve stimulation (taVNS) combined with conventional drug treatment was administered. (Weeks 5-8), taVNS intervention was stopped and only conventiona
Sponsors
Zhejiang Province Lishui City Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Age range: 45 - 85 years old; 2) Those who meet the diagnostic criteria for Parkinson's disease in both traditional Chinese and Western medicine, and the diagnostic criteria for the liver and kidney yin deficiency type of tremor in traditional Chinese medicine (with 2 main symptoms and 1 or more secondary symptoms) (two physicians with the title of associate chief physician or above conduct syndrome differentiation facing each other, ensuring the accuracy of the liver and kidney yin deficiency syndrome type); 3) Voluntary participation in this study and signing the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Those with communication disorders either orally or in writing, and those who cannot cooperate; 2) Those with blood system diseases, malignant tumors, diabetic ketoacidosis or functional failures of the heart, liver, kidney, etc., with critical conditions and those whose conditions are difficult to evaluate for effective treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale III (UPDRS III);Parkinson's Disease Quality of Life Questionnaire 39 (PDQ-39); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hoehn-Yahr Rating Scale (H-Y);Parkinson's Disease Non-Motor Symptoms Rating Scale (NMSS);Berg Balance Scale (BBS);10-meter walking speed test (l0WMT);Timed Up and Go Test (TUGT);30-second sitting-up test (30s-CST);Upper limb functional forward extension test (FRT);Constipation Assessment Scale (CAS);Pittsburgh Sleep Quality Index (PSQI);Hamilton Depression Scale (HAMD);Hamilton Anxiety Scale (HAMA);Traditional Chinese Medicine Syndrome Score;Traditional Chinese Medicine Syndrome Score; | — |
Countries
China
Contacts
Public ContactMa Jincheng
Zhejiang Province Lishui City Hospital of Traditional Chinese Medicine
Outcome results
None listed