Mild Cognitive Impairment
Conditions
Interventions
Electroacupuncture Group:After routine skin disinfection of the acupoints Baihui (GV20), Sishencong (EX-HN1), Shenting (GV24), Yintang (EX-HN3), Fengchi (GB20, bilateral), Yingxiang (LI20, bilateral),
Sham Electroacupuncture Group:The subject assumed a supine position. Non-meridian, non-acupoint locations on the arms and legs were selected as sham points: Sham Point 1: 8 cm proximal to the cubita
Sponsors
the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Diagnostic Criteria: Based on the Western diagnostic criteria proposed by Jak/Bondi in 2014, the following six indicators were used: Delayed free recall (N5) and recognition (N7) scores from the Auditory Verbal Learning Test Huashan version (AVLT) Total score of the Animal Fluency Test (AFT) Total score of the Boston Naming Test (BNT) Total completion time of Shape Trails Test-A and B (STT-A/B) Diagnosis is confirmed if: 1) Two test scores within the same cognitive domain are impaired; 2) Or one test score in each of the three cognitive domains (memory, executive function, language) is impaired; 3) Or activities of daily living are impaired. Among these, aMCI is diagnosed based on the MCI diagnostic criteria, with impairment in AVLT N5 and/or AVLT N7. Inclusion Criteria: (1) Meet the diagnostic criteria for aMCI; (2) Aged between 50 and 85 years (inclusive), regardless of gender; (3) Disease duration exceeding 3 months; (4) Clinical Dementia Rating (CDR) score of 0.5; (5) Ischemic Index score < 4; (6) Ability to comprehend and complete assessments correctly; (7) Voluntary participation and signed informed consent; (8) No contraindications to MRI scanning (e.g., metal implants).
Exclusion criteria
Exclusion criteria: (1) Currently undergoing treatments that may interfere with cognitive function; (2) A history of neurological disorders affecting cognition or systemic diseases leading to cognitive decline, except for individuals with suspected early-stage Alzheimer's disease; (3) Brain magnetic resonance imaging (MRI) findings indicating infections, other focal lesions, multiple infarctions, infarcts in critical memory-related brain regions, or severe white matter lesions; (4) A history of tumors, psychiatric disorders, or severe anxiety and depression; (5) Presence of hemorrhagic diseases, bleeding tendencies, or severe skin infections; (6) Severe drug dependence, smoking, substance abuse, or alcohol addiction; (7) Pregnant or lactating individuals, or those with suspected pregnancy; (8) Having received any acupuncture treatment or participated in other clinical trials within the past six months; (9) Individuals with skin breakdown, infections, or susceptibility to allergies at acupuncture points, or those with claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Assessment Scale-Cognitive Subscale; Pittsburgh Sleep Quality Index;Traditional Chinese Medicine (TCM) Syndrome Score Scale; | — |
Countries
China
Contacts
Public ContactQuan Fei
The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
Outcome results
None listed