Severe pneumonia in the elderly complicated with respiratory failure
Conditions
Interventions
Irrigation group:Routine treatment + bronchoscopic lung lavage with ambroxol. Routine treatment includes anti-infection, anti-inflammatory, fever reduction, and mechanical ventilation for respiratory
Yinqiaosan Formula:Conventional treatment combined with modified Yin Qiao San therapy
Sponsors
North China university of science and technology affiliated hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Diagnosed with severe pneumonia (SP) according to the 'Chinese Expert Consensus on Clinical Practice of Severe Pneumonia in Emergency Departments'; (2) Presence of respiratory failure (RF); (3) Age = 60 years, regardless of gender; (4) Meeting the diagnostic criteria for phlegm-heat blocking the lungs syndrome as specified in the 'Guidelines for Traditional Chinese Medicine Diagnosis and Treatment of Community-Acquired Pneumonia' and the 'Diagnostic and Therapeutic Efficacy Standards for TCM Diseases': thick yellow sputum, severe cough with chest pain, high fever with restlessness, chest fullness and shortness of breath; poor spirit, chest pain with dry mouth, yellow urine and constipation; tongue and pulse manifestations include red tongue, yellow or greasy yellow coating, rapid or slippery rapid pulse; (5) Disease course = 72 hours; (6) The patient or their legal representative has signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1) There are contraindications for bronchoscopy such as active massive hemoptysis, severe arrhythmia, aortic aneurysm, severe pulmonary hypertension, etc.; (2) Respiratory failure caused by non-infectious lung diseases such as acute pulmonary embolism and cardiogenic pulmonary edema; (3) Accompanied by other lung diseases such as lung cancer and pulmonary tuberculosis; (4) Accompanied by severe dementia or mental illness; (5) Accompanied by other serious physical diseases such as severe liver and kidney dysfunction, cardiovascular and cerebrovascular diseases; (6) Allergic constitution
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time taken for clinical symptoms to improve; | — |
Secondary
| Measure | Time frame |
|---|---|
| White blood cell count;Neutrophil count;Neutrophil-to-lymphocyte ratio;C-reactive protein;Galactose-binding lectin-3;a1-Antitrypsin;Interleukin 6;Interleukin 18;Mainly Organizational Compatibility Complex I-related Molecular Scoring Scale;Adverse reactions; | — |
Countries
China
Contacts
Public Contactwuchunli
North China university of science and technology affiliated hospital
Outcome results
None listed