Septic myocarditis
Conditions
Interventions
Patients with left ventricular dysfunction based on echocardiographic assessment.:Not applicable
The patients with right heart dysfunction based on echocardiographic assessment.:Not applicable
Sponsors
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patient age = 18 years; Meets the diagnostic criteria for sepsis according to "Sepsis-3.0"; Able to complete baseline assessments within 24 hours after sepsis confirmation, including collection of clinical data and standardized echocardiography; The subject or their legal representative signs the informed consent form. If unable to sign due to altered mental status, the emergency deferred consent procedure is initiated in accordance with ethical requirements, and the representative must sign within 48 hours.
Exclusion criteria
Exclusion criteria: Prior to the onset of sepsis, there is a clear, irreversible severe chronic cardiac dysfunction, including but not limited to: a history of NYHA class>III, with no echocardiographic evidence of left ventricular ejection fraction (LVEF) >= 50% within the past 6 months; LVEF < 40% (based on reliable echocardiography within 6 months prior to onset); severe valvular disease requiring intervention (e.g., aortic stenosis with peak velocity <= 4 m/s, valve area < 1.0 cm²; severe mitral regurgitation with left ventricular enlargement); ;. Having undergone cardiac transplantation or implantation of a ventricular assist device (e.g., LVAD); This hospitalization is diagnosed as acute coronary syndrome (ACS), specifically including: coronary angiography showing culprit vessel stenosis = 70% or dynamic electrocardiographic changes and elevated troponin levels consistent with myocardial infarction criteria; Concomitant end-stage renal disease (eGFR < 15 mL/min/1.73m²); Concomitant advanced malignancy with an expected survival of < 6 months; Unable to complete standardized cardiac echocardiography within 72 hours due to anatomical or pulmonary reasons (e.g., severe emphysema, rib fractures); Pregnant patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Echocardiogram Results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation and immune-related biomarkers laboratory test results.;hemodynamic parameters;Demographic information;Basic Medical History Information;Long-term medication history information;The Information of the Four Diagnostic Methods and Syndrome Elements in Traditional Chinese Medicine;Vital signs (body temperature, heart rate, respiratory rate, peripheral oxygen saturation, mean arterial pressure);Severity of illness scoring (SOFA score, APACHE II score, Glasgow Coma Scale score);Hemodynamic indices; | — |
Countries
China
Contacts
Public ContactLi Jun
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Outcome results
None listed