Primary ovarian insufficiency
Conditions
Interventions
Acupuncture combined with Western medicine treatment group:Patients in the acupuncture plus medication group received acupuncture treatment three times per week for three consecutive months, in additi
Sham Acupuncture combined with Western medicine treatment group:Patients in the sham acupuncture plus medication group received sham acupuncture using a retractable needle device designed to simulate
Sponsors
Yunnan Minzu University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Female patients with Primary ovarian insufficiency who meet the diagnostic criteria of Western medicine; 2. Aged 18–40 years; 3. Right-handed; 4. Spontaneous amenorrhea or menstrual irregularity for =4 months; 5. Elevated follicle-stimulating hormone (FSH) concentration, =25 IU/L; 6. Willing to participate and able to provide written informed consent. Participants who meet all of the above inclusion criteria will be considered eligible for enrollment.
Exclusion criteria
Exclusion criteria: 1. Congenital maldevelopment of the reproductive organs; 2. Amenorrhea secondary to acquired causes, including organic disorders of the reproductive system, prior ovarian surgery, chemotherapy, use of hormonal agents or immunosuppressive drugs, or other iatrogenic injuries; 3. Age > 40 years; 4. Contraindications to hormonal therapy, such as breast tumors, endometrial carcinoma, abnormal uterine bleeding, or a history of cardiovascular or cerebrovascular infarction; 5. Presence of severe comorbidities involving the cardiovascular or cerebrovascular, nervous, hematologic, immune, digestive systems, thyroid dysfunction, chronic hepatic or renal insufficiency, or malignant tumors; 6. A previous or current diagnosis of schizophrenia; 7. Participation in another clinical trial within 30 days prior to enrollment; 8. Skin diseases, limb defects, or other conditions at the selected acupoint sites that preclude the administration of acupuncture; 9. History of allergy to acupuncture or severe needle phobia; 10. Contraindications to magnetic resonance imaging, such as the presence of non-removable metallic implants or claustrophobia; 11.Pregnant or lactating women. Participants meeting any one of the above exclusion criteria will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to menstrual cycle recovery(days); | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Kupperman Rating Scale;Hamilton Anxiety Rating Scale;Hamilton Depression Rating Scale;SF-12 Quality of Life Questionnaire;Changes in blood flow and blood oxygenation triggered by neuronal activity;Heart rate variability;Ovarian volume, number of antral follicles, size of the uterus, etc.;Follicle-Stimulating Hormone, Anti-Müllerian Hormone, etc.;Pittsburgh Sleep Quality Index; | — |
Countries
China
Contacts
Public Contactzhou yuanfang
Yunnan Minzu University
Outcome results
None listed