Respiratory failure
Conditions
Interventions
Control group:Endotracheal intubation with invasive mechanical ventilation, routine symptomatic treatment
Treatment group:Endotracheal intubation with invasive mechanical ventilation, supplemented with modified Bu Zhong Yi Qi Tang formula in addition to routine symptomatic treatment.
Sponsors
The Second Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Diagnostic Criteria for Respiratory Failure: Confirmed diagnosis of "respiratory failure" based on arterial blood gas analysis. Criteria for Difficulty in Weaning: 1) Failure of SBT; 2) Death within 48 hours post-extubation 3) Use of NIV within 48 hours post-extubation; 4) Reintubation within 48 hours post-extubation. Age =18 years; Meets the above diagnostic criteria; Meets the weaning failure criteria following initial SBT failure; Intubated and connected to invasive mechanical ventilation via a ventilator; Duration of mechanical ventilation >48 hours; No occurrence of deep coma; Family voluntarily signs informed consent.
Exclusion criteria
Exclusion criteria: Patients with difficult extubation due to neurological or muscular disorders; those with severe hepatic or renal insufficiency, irreversible brain death, or other conditions; patients with multiple organ dysfunction; those in severe coma or shock; individuals with allergic constitutions; those with unstable vital signs during observation or who die within 48 hours post-extubation; or those experiencing other severe complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hypoxia inducible factor-1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Basic Information;Time from initial Spontaneous Breathing Trial failure to successful extubation;Duration of mechanical ventilation;Mechanical Ventilation Mode;Ventilator Parameters;Primary disease;APACHE II Score;Glasgow Coma Scale (GCS);Arterial Blood Gas Analysis; | — |
Countries
China
Contacts
Public ContactLiu Rui
The Second Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed