Graves disease
Conditions
Interventions
Combination Therapy Group:The combination of and therapy
Western medicine control group:Basic treatment of Western medicine
Sponsors
Shanghai University of Traditional Chinese Medicine Affiliated Municipal Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Age 18–70 years; Meets the diagnostic criteria for Graves' disease, based on the "Chinese Guidelines for the Diagnosis and Treatment of Hyperthyroidism and Other Causes of Thyrotoxicosis" and the "2016 American Thyroid Association Guidelines for the Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis," with at least 2 of the following: typical hyperthyroidism manifestations (palpitations, sweating, weight loss, tremors, diffuse goiter, exophthalmos, etc.); laboratory indicators: TSH < 0.1 mIU/L, elevated FT4 and/or FT3, positive TRAb; imaging: thyroid ultrasound showing diffuse enlargement with rich blood flow. Prospective cohort patients provide informed consent; Meets the above criteria and does not have any of the exclusion criteria.
Exclusion criteria
Exclusion criteria: Pregnant or breastfeeding women; Severe heart/liver/kidney dysfunction (ALT > 3xULN, eGFR < 60 ml/min/1.73m2); Abnormal blood routine: white blood cells <3x10^9/L, neutrophils <1.5x10^9/L, or accompanied by other malignant hematological diseases; Coexisting other systemic autoimmune diseases or malignant tumors; Previous history of subtotal thyroidectomy or radioactive iodine-131 therapy; Allergy to MMI or herbal components used in the study; Failure to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dynamic changes in TRAb levels (IU/L) and the proportion turning negative;18-month discontinuation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic Changes in Levels of FT3, FT4, TSH, and TSI;Biochemical recovery time: the first time TSH, FT4, and FT3 return to normal levels.;Recurrence Rate and Recurrence Time; | — |
Countries
China
Contacts
Public ContactChen Yi
Shanghai City Hospital of Traditional Chinese Medicine
Outcome results
None listed