intrauterine adhesion
Conditions
Interventions
treatment group:The treatment group was treated with the basic therapy of (intrauterine adhesion decomposition surgery + sequential treatment with estrogen and progesterone + tonifying kidney and prom
control group:The control group was treated with the basic therapy of (intrauterine adhesion decomposition surgery + sequential treatment with estrogen and progesterone) for 3 months
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Meet the above-mentioned diagnostic criteria of both traditional Chinese and Western medicine; (2) Age 25 to 40 years old; (3) No hormone therapy has been carried out in the past three months; (4) There was no need for pregnancy within 3 months after enrollment; (5) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Combined with other endocrine diseases, such as: polycystic ovary syndrome, hypothalamic-pituitary dysfunction, thyroid dysfunction, etc. (2) Combined with other organic diseases of the uterus and fallopian tubes, such as: uterine malformations, endometriosis, adenomyosis, uterine fibroids, endometrial polyps, chronic endometritis, untreated hydrosalpinx, etc. (3) Those with other immune deficiencies or malignant tumors; (4) Patients with a history of drug allergy or contraindications; (5) Those suffering from mental illness; (6) Those who are treated with other antidepressant traditional Chinese medicine or Western medicine; (7) Exclude those who are pregnant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| endometrial thickness;Uterine artery blood flow index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factor indicators (IL-6, IL-8, TNF-a) in uterine cavity fluid;Fibrosis indicators (ECM degradation-related factors (MMP-9, TIMP-1) mRNA, COL1A1 mRNA, a-SMA mRNA);Autophagy indicators (LC3-II mRNA, SQSTM1/p62 mRNA, AGT5 mRNA), Akt mRNA, mTOR mRNA;Intrauterine microorganisms;Scoring of TCM Syndromes;Evaluation of menstrual flow; | — |
Countries
China
Contacts
Public ContactZhang Xiaole
Shuguang Hospital Affiliated to Shanghai University of TCM Shanghai
Outcome results
None listed