Acute Gastrointestinal Dysfunction
Conditions
Interventions
ContentAI Regulation Electroacupuncture Central Regulatory Group:1.Acupuncture Point Selection: Based on the principles of Traditional Chinese Medicine (TCM) meridian theory and clinical experience, t
Sponsors
Zhejiang Provincial Tongde Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of Sepsis 3.0: there is evidence of infection and the Sequential Organ Failure Assessment (SOFA) score is =2 points. 2. Combined with acute gastrointestinal dysfunction (AGI), meeting any of the following conditions: According to the AGI grading standard (2016 version), reaching grade II or above (risk or early manifestation of gastrointestinal dysfunction and failure). Clinical manifestations: symptoms of gastrointestinal motility disorders such as abdominal distension, vomiting, weakened or disappeared bowel sounds, increased gastric residual volume (>200 ml) lasting for = 24 hours. 3. Patients should be included in the study within 48-72 hours after sepsis diagnosis. 4. Have not received electroacupuncture treatment or other traditional Chinese medicine interventions for gastrointestinal dysfunction. 5. Vital signs are relatively stable: systolic blood pressure =90 mmHg (or maintained with the support of vasoactive drugs), heart rate =120 beats/min, and respiratory rate =30 beats/min. 6. Consciousness status: Glasgow Coma Scale (GCS) =10 points (can cooperate with treatment evaluation). 7. The patient or his legal guardian has signed a written informed consent form and agreed to participate in the research and related treatment operations. 8. Age 18-75, no gender limit.
Exclusion criteria
Exclusion criteria: 1. Combined with other severe organ failure: such as acute liver failure (bilirubin >3 times the upper limit of normal), acute renal failure (requiring renal replacement therapy), cardiogenic shock. 2. There are organic diseases of the gastrointestinal tract: such as gastrointestinal perforation, intestinal obstruction, intestinal ischemia, severe gastric ulcer (with risk of bleeding). 3. Platelets <50×10^9/L, coagulation disorder or bleeding tendency. 4. Contraindications for electroacupuncture treatment: skin infection, ulcer, scar or tumor at the acupuncture site. Installation of a pacemaker or other electronic implant. Are allergic to electrical stimulation or cannot tolerate electroacupuncture stimulation. 5. Are receiving other interventions that may affect gastrointestinal function: such as continuous gastrointestinal decompression (except when necessary for diagnosis), other traditional Chinese medicine acupuncture treatments, high-dose gastrointestinal motility drugs (such as erythromycin, mosapride), etc. 6. Pregnant or lactating women. 7. Have mental illness or cognitive impairment and are unable to cooperate with treatment and follow-up. 8. The expected survival time is <72 hours or the condition worsens rapidly and emergency surgery is required. 9. Participated in other clinical trials within the past month. 10. Other conditions that the researcher believes are not suitable for inclusion in the study (such as severe electrolyte imbalance, uncorrectable hypoxemia, etc
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal function indicators (intra-abdominal pressure, gastric residual volume, bowel sound frequency);Inflammation and Immune Indices;Traditional Chinese Medicine Syndrome Criteria; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality rate; | — |
Countries
China
Contacts
Public ContactJianbiao Meng
Zhejiang Provincial Tongde Hospital
Outcome results
None listed