Low Anterior Resection Syndrome
Conditions
Interventions
experimental group:In addition to basic supportive care, participants will receive Yiqi Lifu dietary product Yifu II (fruit?vegetable juice beverage)? for continuous administration over 14 days.
control group:Outside of routine supportive care (dietary guidance? and pelvic floor rehabilitation training), no other medications that may affect outcome assessment will be administered. If, after 1
local physical therapies may include anal irrigation? and percutaneous tibial nerve stimulation (PTNS). The specific treatment regimen shall be determined by the clinical investigator following assess
Sponsors
Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age between 18 and 75 years; gender unrestricted.? (2) Within one month after rectal resection, anastomosis located below the peritoneal reflection, meeting diagnostic criteria for Low Anterior Resection Syndrome (LARS).? (3) No prophylactic stoma, no postoperative complications, and able to eat normally.? (4) Patient has signed informed consent form, demonstrates good compliance, and agrees to follow-up visits and re-examinations.
Exclusion criteria
Exclusion criteria: (1)? Undergoing other types of colorectal cancer surgery or resection of other intestinal segments (e.g., Hartmann procedure, pelvic exenteration, transanal endoscopic microsurgery [TEM], or sigmoidectomy). (2)? Undergoing other pelvic surgery for non-tumor reasons. (3)? Preoperative fecal incontinence. (4)? Diagnosed with inflammatory bowel disease (IBD)? or irritable bowel syndrome (IBS). (5)? Poorly controlled diabetes, diabetic ketoacidosis (DKA), or hyperosmolar hyperglycemic state (HHS). (6)? Pregnant? or planning pregnancy within the next 6 months; breastfeeding? women. (7)? Known or suspected allergy? to the study dietary product(s). (8)? Individuals with psychiatric disorders? or cognitive impairment. (9)? Suspected or confirmed alcohol addiction? or history of drug abuse. (10)? Participation in another interventional clinical study? within the past 30 days? prior to screening. (11)? Currently participating in another clinical trial. (12)? Deemed by the investigator? to be unsuitable for participation in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Low Anterior Resection Syndrome Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wexner Fecal Incontinence Scale;EORTC-QLQ-C30 Quality of Life Scale;The proportion of patients with improved bowel dysfunction;Subjective distress of intestinal symptoms; | — |
Countries
China
Contacts
Public ContactLiang Jianwei
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed