major depressive disorder
Conditions
Interventions
Escitalopram combined with transabdominal electroacupuncture treatment group:Transabdominal electro-acupuncture at Tianshu (ST25) and Da Qinji (SP15) for treatment: 1) Needle insertion depth: Use a 50
2) Electro-acupuncture parameters: Connect the electro-acupuncture device (Tianshu +, Da Qinji -), use a 3-5 Hz continuous wave, wave width 500 µs, current intensity 8-10 mA, continuous stimulation fo
3) Treatment frequency: Once a day, 5 treatments per week, continuous treatment for 2 weeks.
Escitalopram combined with sham electroacupuncture treatment group:Fake electro-acupuncture treatment: Make a shallow incision at a non-acupoint on one side (1 inch away from the acupoint), without an
Sponsors
Zhongda Hospital Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Meets the diagnostic criteria for depression as defined in DSM-5; 2) Screening and baseline Hamilton Depression Scale: HAMD-24-item score = 20 points; 3) Age 18-65 years (inclusive of 18 and 65), regardless of gender; 4) Within two weeks prior to enrollment, no antipsychotic drugs, mood stabilizers, or antidepressants have been taken by the patient; 5) The patient or their legal guardian has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Has a history of schizophrenia, bipolar disorder, alcohol and drug dependence; 2) Has severe suicidal behavior or thoughts; 3) Has a brain organic disease; 4) Has malignant tumors or severe abnormalities in heart, liver, or kidney functions; 5) Pregnant or lactating women; 6) Those currently participating in other drug clinical studies or receiving long-term acupuncture treatment; 7) Those with abdominal skin injuries or infections, acute abdominal inflammations or organic lesions, early post-abdominal surgery or unhealed wounds; 8) Those with severe bleeding tendencies or coagulation disorders, acute infectious diseases or high fever conditions; 9) Those intolerant or allergic to electrical stimulation, or those with implanted electronic devices in their bodies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD-24); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale (HAMA);The Intestinal Irritable Bowel Syndrome Severity Scoring Scale (IBS-SSS);Gastrointestinal Symptom Rating Scale (GSRS); | — |
Countries
China
Contacts
Public ContactZhi Xu
Zhongda Hospital Southeast University
Outcome results
None listed