Knee osteoarthritis with comorbid subthreshold depression
Conditions
Interventions
Electroacupuncture group:Electroacupuncture
Sham electroacupuncture group:Sham electroacupuncture
Sponsors
Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnostic criteria: (1) Knee osteoarthritis: meets the diagnostic criteria for knee osteoarthritis established by the American College of Rheumatology [3,4]. (2) Depressive state: Meets the diagnostic criteria for subthreshold depression in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders, and has 7 = 17 Hamilton Depression Scale scores<17 points [5]. 2. Inclusion criteria: (1) Age between 40-75 years old, gender not limited. (2) Meets the diagnostic criteria for knee osteoarthritis and depression mentioned above. (3) Within 2 weeks prior to enrollment, no knee joint injection, systemic hormone or antidepressant treatment has been received, or stable dose antidepressant treatment has been received for at least 4 weeks and agreed to maintain the dose unchanged during the study period. (4) Voluntarily participate in this study and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: (1) Knee pain caused by other diseases such as rheumatoid arthritis, gouty arthritis, traumatic arthritis, etc. (2) Suffering from severe mental illness (such as schizophrenia, bipolar disorder, severe suicidal tendencies, etc.) or cognitive impairment, unable to cooperate in completing the study. (3) Patients who have undergone surgery on their knee joint or plan to undergo surgery during the study period. (4) Merge severe primary diseases such as heart, brain, liver, kidney, and hematopoietic system. (5) Pregnant or lactating women. (6) Acupuncture faintness or fear of acupuncture and moxibustion treatment. (7) The acupuncture site (Yanglingquan, Zusanli, Baihui, Yintang) has local skin damage or infection. (8) Participants who have participated in other clinical trials within the past 3 months. (9) Individuals with clear gastrointestinal organic diseases or functional disorders within the past 3 months, such as inflammatory bowel disease (Crohn's disease, ulcerative colitis), irritable bowel syndrome, chronic constipation or diarrhea, as well as a history of gastrointestinal surgery (excluding appendectomy). (10) He has suffered from acute infectious diseases or used drugs that may significantly affect the intestinal flora in the past month, including systemic antibiotics, proton pump inhibitors, and systemic immunosuppressants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index; Hamilton Depression Rating Scale 17-item (HAMD-17);Beck Depression Inventory-II;Numeric Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Short-Form Six-Dimension;Zung Self-Rating Anxiety Scale;Pittsburgh Sleep Quality Index ; | — |
Countries
China
Contacts
Public ContactXiumin Jiang
Fujian University of Traditional Chinese Medicine Affiliated Rehabilitation Hospital
Outcome results
None listed